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Perioperative Homocysteine an...

Perioperative Homocysteine and Postoperative Complications/All-Cause Mortality in Elderly Non-Cardiac Surgery Patients

Last Updated: 2025-05-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

12955 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-01-01

Study Completion Date

2020-08-30

Brief Summary

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This study aims to explore the association between perioperative homocysteine (Hcy) levels and their pre-to-postoperative changes with postoperative complications and all-cause mortality in elderly patients undergoing non-cardiac surgery. Besides, the dynamic changes in Hcy levels may reflect metabolic shifts, highlighting their potential value in predicting adverse postoperative outcomes. These findings suggest that monitoring perioperative Hcy levels and their changes could help identify high-risk patients and inform postoperative management strategies.

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Detailed Description

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Conditions

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Elderly Homocysteinemia AKI - Acute Kidney Injury Mortality Postoperative

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Hospitalized older (≥ 65 years) patients underwent non-cardiac surgery

Exclusion Criteria

* 21227 patients without preoperative Hcy data
* 957 patients undergoing neurosurgery
* 3 patients call off the surgery for reasons
* 164 patients with chronic kidney disease

Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers