The Relationship Between Anticholinergic Burden and Postoperative Complications After Cardiac Surgery in Older Adults

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-04-01

Study Completion Date

2022-12-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Drugs with anticholinergic properties are widely prescribed in the elderly population, despite increasing evidence in the literature regarding side effects and adverse outcomes. As is known, many drugs have anticholinergic activity, which means that they block the binding of the neurotransmitter acetylcholine to the muscarinic receptor. In this case, the occurrence of anticholinergic side effects becomes inevitable. Central effects such as cognitive impairment, dizziness, sedation, confusion or delirium, and peripheral effects such as dry mouth, dry eyes, constipation, urinary retention, and tachycardia begin to be seen in patients. Anticholinergic load refers to the cumulative effect of taking one or more drugs with anticholinergic activity. This cumulative effect is a strong indicator of cognitive and physical deterioration, especially in the elderly population. It is also associated with adverse outcomes such as falls, impaired functioning, and higher rates of hospitalization and death.

Anticholinergic load scales include scales that facilitate the work of physicians used in clinical practice to predict anticholinergic side effects in humans. Although there are many different scales used at this point, one of the scales with the highest validity and reliability in recent studies are Anticholinergic cognitive burden scale (ACB) and Anticholinergic risk scale (ARS). To the best of our knowledge, we could not find any study on postoperative complications, length of hospital stay and mortality after cardiac surgery with these scales. Therefore, we aimed to examine the relationship between possible complications after cardiac surgery and anticholinergic load scales showing the cumulative effect of preoperative drugs.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

The Effect of the Anticholinergic Burden Following Elective Coronary Artery Surgery

NCT06349057

Postoperative Recovery Length of Hospital Stay Postoperative Complications

RECRUITING PHASE4

Delirium in Elderly Undergoing Cardiac Surgery and the Significance of CholinEsterase Activity

NCT02631304

Postoperative Complications

COMPLETED

Effect of the Anticholinergic Drug Burden on Postoperative Delirium in Elderly Chinese Patients: A Nested Case-Control Study

NCT06931353

Delirium - Postoperative

COMPLETED

Anesthesia Geriatric Evaluation and Quality of Life After Cardiac Surgery

NCT02535728

Quality of Life

COMPLETED

Association Between Burst Suppression During Anesthetic Induction With Postoperative Delirium in Cardiac Surgery

NCT04713644

Postoperative Delirium

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Postoperative Complications

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

High anticholinergic burden

ACB scale score 1 or \>1 as a high anticholinergic buden

cardiac surgery

Intervention Type PROCEDURE

cardiovascular surgery including valve repair/replacement or CABG or combined procedures

Normal anticholinergic burden

ACB scale score \<1 as a control group

cardiac surgery

Intervention Type PROCEDURE

cardiovascular surgery including valve repair/replacement or CABG or combined procedures

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

cardiac surgery

cardiovascular surgery including valve repair/replacement or CABG or combined procedures

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* It is planned to include patients over the age of 65 who underwent cardiac surgery in the research population.
* Gender discrimination will not be considered.