Researching the Affect of Sevoflurane in Cardiac Surgery on Delirium

NCT ID: NCT05365165

Last Updated: 2022-05-09

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 2 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2022-03-15
• Study Completion Date: 2022-10-31

Brief Summary

Many risk factors have been identified for delirium after open heart surgery . One of the main risk factors; duration of stay on mechanical ventilator . Our hypothesis; The use of sevoflurane during aortic cross-clamping reduces the need for long-acting intravenous anesthetic agents. Therefore, patients will be weaned from the mechanical ventilator in a shorter time. Patients with shorter stays on mechanical ventilation develop less postoperative delirium.

Detailed Description

Standard anesthesia management will be applied in the induction and maintenance of anesthesia. In the induction of anesthesia 1mg/kg lidocaine , 1.5-2mg/kg propofol , 1 mcg /kg fentanyl citrate, 0.6 mg/kg rocuronium bromide will be administered. Sevoflurane for maintenance of anesthesia and propofol and fentanyl if needed bolus will be applied. BIS monitoring will be performed to control the depth of anesthesia. Patients' peroperative hemodynamic levels, arterial blood gas levels, operation time, pump time, aortic cross clamp time, postoperative complications , the amount of blood and fluid used, the amount of iv anesthetic used, the extubation time, the length of stay in the intensive care unit, the length of stay in the hospital will be followed and recorded. Postoperative delirium follow-ups of the patients will be recorded once a day by the same investigator using the Nursing Delirium Screening Scale and Delirium Rating Scale Revised-98 until they are discharged from the hospital .

Conditions

Postoperative Delirium

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

sevoflurane

Standard anesthesia management will be applied in the induction and maintenance of anesthesia. In the induction of anesthesia 1mg/kg lidocaine , 1.5-2mg/kg propofol , 1 mcg /kg fentanyl citrate, 0.6 mg/kg rocuronium bromide will be administered. Sevoflurane for maintenance of anesthesia and propofol and fentanyl if needed bolus will be applied. BIS monitoring will be performed to control the depth of anesthesia.

Sevoflurane

Intervention Type: DRUG

Sevoflurane will be applied during aortic cross- clamping in cardiac surgery

Interventions

Sevoflurane

Sevoflurane will be applied during aortic cross- clamping in cardiac surgery

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

Patients with a score of 25 and above in the mini-mental state test performed in the preoperative period

Exclusion Criteria

Those who are scheduled for emergency surgery

Those with known dementia and/or neurological disease

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Derince Training and Research Hospital

OTHER

Sponsor Role: lead

Responsible Party

Aysegul Cigdem Caglayan

MD, Anesthesiology and Reanimation

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Ayşegül Çiğdem Çağlayan

Kocaeli, , Turkey (Türkiye)

Site Status: RECRUITING

Countries

Turkey (Türkiye)

Central Contacts

Mehmet Yılmaz

Role: CONTACT

drmyilmaz33@gmail.com

+902623178000

Facility Contacts

çiğdem çağlayan

Role: primary

cigdemxyalcin@gmail.com

+905055347107

Other Identifiers

DERINCETRHCCAGLAYAN002

Identifier Type: -

Identifier Source: org_study_id