Exploration of Risk Factors for Postoperative Cerebral Infarction in Lung Cancer Patients: a Retrospective Single-centre Study

NCT ID: NCT06942845

Last Updated: 2025-04-24

Basic Information

• Recruitment Status: ACTIVE_NOT_RECRUITING
• Total Enrollment: 300 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2025-04-01
• Study Completion Date: 2025-12-01

Brief Summary

Lung cancer remains the world's leading cancer in terms of morbidity and mortality, with more than 20 million new cases and 9.7 million deaths annually. Despite improvements in surgical techniques and medical care, the number of elderly people undergoing surgery is gradually increasing, so there are an increasing number of complications following lung resection. Postoperative cerebral infarction is a relatively rare but devastating complication that places a heavy burden on patients and families. The incidence of postoperative cerebral infarction in patients after thoracic surgery has been reported to be 0.6-1.1%. There is a risk of postoperative cerebral infarction after lung cancer surgery, and the results of a few studies have shown that postoperative cerebral infarction is related to old age, male, hypertension, hyperlipidemia, and lobectomy factors, but the pathogenesis of the occurrence of cerebral infarction has not been clearly proved for the time being, and so these risk factors cannot be taken as the direct cause of cerebral infarction. Therefore, we need to further explore the factors leading to cerebral infarction after lung cancer surgery. If we can further prove that some of the risk factors are related to the causes of cerebral infarction after lung cancer surgery, we can make corresponding strategies in the perioperative period to improve the safety of surgery and reduce the incidence of cerebral infarction in the postoperative period.

Conditions

Lung Cancer, Non-Small Cell; Postoperative Cerebral Infarction

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: RETROSPECTIVE

Study Groups

Postoperative cerebral infarction

non-intervention

Intervention Type: OTHER

non-intervention

No postoperative cerebral infarction

non-intervention

Intervention Type: OTHER

non-intervention

Interventions

non-intervention

non-intervention

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

Postoperative cerebral infarction

Exclusion Criteria

No postoperative infarction

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Xinghua Cheng

OTHER

Sponsor Role: lead

Responsible Party

Xinghua Cheng

deputy chief physician

Responsibility Role: SPONSOR_INVESTIGATOR

Locations

Shanghai Chest Hospital

Shanghai, , China

Countries

China

References

Nishizawa N, Okawara M, Mori M, Fujino Y, Matsuda S, Fushimi K, Tanaka F. Postoperative cerebral infarction risk is related to lobectomy site in lung cancer: a retrospective cohort study of nationwide data in Japan. BMJ Open Respir Res. 2022 Jul;9(1):e001327. doi: 10.1136/bmjresp-2022-001327.

Reference Type: BACKGROUND

PMID: 35868837 (View on PubMed)

Matsumoto K, Sato S, Okumura M, Niwa H, Hida Y, Kaga K, Date H, Nakajima J, Usuda J, Suzuki M, Souma T, Tsuchida M, Miyata Y, Nagayasu T. Frequency of cerebral infarction after pulmonary resection: a multicenter, retrospective study in Japan. Surg Today. 2018 May;48(5):571-572. doi: 10.1007/s00595-017-1620-9. Epub 2018 Jan 11. No abstract available.

Reference Type: BACKGROUND

PMID: 29327086 (View on PubMed)

Gao S, Zhou Y, Yang R, Du C, Wu Y. Risk factors for postoperative cerebral infarction in patients after lung resection: a single-center case-control study. J Thorac Dis. 2023 Feb 28;15(2):376-385. doi: 10.21037/jtd-22-1019. Epub 2023 Jan 16.

Reference Type: BACKGROUND

PMID: 36910048 (View on PubMed)

Hattori A, Takamochi K, Kitamura Y, Matsunaga T, Suzuki K, Oh S, Suzuki K. Risk factor analysis of cerebral infarction and clinicopathological characteristics of left upper pulmonary vein stump thrombus after lobectomy. Gen Thorac Cardiovasc Surg. 2019 Feb;67(2):247-253. doi: 10.1007/s11748-018-1017-8. Epub 2018 Sep 24.

Reference Type: BACKGROUND

PMID: 30251002 (View on PubMed)

Nojiri T, Inoue M, Takeuchi Y, Maeda H, Shintani Y, Sawabata N, Hamasaki T, Okumura M. Impact of cardiopulmonary complications of lung cancer surgery on long-term outcomes. Surg Today. 2015 Jun;45(6):740-5. doi: 10.1007/s00595-014-1032-z. Epub 2014 Sep 19.

Reference Type: BACKGROUND

PMID: 25236860 (View on PubMed)

Other Identifiers

postoperative cerebral infarct

Identifier Type: -

Identifier Source: org_study_id