Six Minutes Walk Test in Children on Regular Hemodialysis

NCT ID: NCT06910319

Last Updated: 2025-04-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-05-01

Study Completion Date

2026-06-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

To evaluate exercise tolerance and the reproducibility of the six minute walk test in children and adolescents with ESRD on regular hemodialysis and to compare their functional exercise capacities with reference values for healthy children. To investigate predictors of poor 6MWT performance in children on regular HD

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The six-minute walk test (6MWT) is a submaximal test that assesses the functional exercise capacities of healthy subjects or those with a chronic disease, as well as the effects of interventions, such as pulmonary rehabilitation or drug therapies. It can predict prognosis, mortality and morbidity in adults and children with lung and/or heart diseases . A study with of children with stage V chronic kidney disease (CKD) has used the 6MWT to demonstrate decreased exercise tolerance , which appears to be caused by several factors, such as anemia, metabolic acidosis, electrolyte imbalance, osteopenia, growth deficiency, malnutrition, inactivity, uremic muscle dysfunction and associated comorbidities . The findings of this study suggest that the 6MWT could be used as a clinical tool to monitor functional exercise capacity in children with kidney disease. The 6MWT is a sub-maximum effort test that is more representative of daily life activities than other effort tests and has low cost and easy applicability . The distance walked in the 6MWT shows an association with VO2 peak, making it a viable and safe alternative for patients who cannot tolerate the ergometric test .

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Hemodialysis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Children with ESRD who on regular hemodialysis at Assiut University Children Hospital .

Exclusion Criteria

* Any subject with underlying primary cardio-pulmonary disease or condition that interfere with the walk test as hemiplegia and cerebral palsy.
Minimum Eligible Age

1 Year

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Assiut University

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Caroline Fayez Abdelmalak

Doctor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Ahlam Badawy Ali, Assistant professor of pediat

Role: PRINCIPAL_INVESTIGATOR

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Caroline Fayez Abdelmalak, Pediatric residant doctor

Role: CONTACT

01221010974

Salah Eldin Amry Ahmad, Professor of pediatrics

Role: CONTACT

‪011 46082024‬

References

Explore related publications, articles, or registry entries linked to this study.

Watanabe FT, Koch VH, Juliani RC, Cunha MT. Six-minute walk test in children and adolescents with renal diseases: tolerance, reproducibility and comparison with healthy subjects. Clinics (Sao Paulo). 2016 Jan;71(1):22-7. doi: 10.6061/clinics/2016(01)05.

Reference Type BACKGROUND
PMID: 26872080 (View on PubMed)

Lipkin DP, Scriven AJ, Crake T, Poole-Wilson PA. Six minute walking test for assessing exercise capacity in chronic heart failure. Br Med J (Clin Res Ed). 1986 Mar 8;292(6521):653-5. doi: 10.1136/bmj.292.6521.653.

Reference Type BACKGROUND
PMID: 3081210 (View on PubMed)

Gayda M, Temfemo A, Choquet D, Ahmaidi S. Cardiorespiratory requirements and reproducibility of the six-minute walk test in elderly patients with coronary artery disease. Arch Phys Med Rehabil. 2004 Sep;85(9):1538-43. doi: 10.1016/j.apmr.2003.11.037.

Reference Type BACKGROUND
PMID: 15375831 (View on PubMed)

Painter P. Physical functioning in end-stage renal disease patients: update 2005. Hemodial Int. 2005 Jul;9(3):218-35. doi: 10.1111/j.1492-7535.2005.01136.x.

Reference Type BACKGROUND
PMID: 16191072 (View on PubMed)

Bittner V, Weiner DH, Yusuf S, Rogers WJ, McIntyre KM, Bangdiwala SI, Kronenberg MW, Kostis JB, Kohn RM, Guillotte M, et al. Prediction of mortality and morbidity with a 6-minute walk test in patients with left ventricular dysfunction. SOLVD Investigators. JAMA. 1993 Oct 13;270(14):1702-7.

Reference Type BACKGROUND
PMID: 8411500 (View on PubMed)

Savci S, Inal-Ince D, Arikan H, Guclu-Gunduz A, Cetisli-Korkmaz N, Armutlu K, Karabudak R. Six-minute walk distance as a measure of functional exercise capacity in multiple sclerosis. Disabil Rehabil. 2005 Nov 30;27(22):1365-71. doi: 10.1080/09638280500164479.

Reference Type BACKGROUND
PMID: 16372431 (View on PubMed)

Du H, Newton PJ, Salamonson Y, Carrieri-Kohlman VL, Davidson PM. A review of the six-minute walk test: its implication as a self-administered assessment tool. Eur J Cardiovasc Nurs. 2009 Mar;8(1):2-8. doi: 10.1016/j.ejcnurse.2008.07.001. Epub 2008 Aug 9.

Reference Type BACKGROUND
PMID: 18694656 (View on PubMed)

Painter P, Krasnoff J, Mathias R. Exercise capacity and physical fitness in pediatric dialysis and kidney transplant patients. Pediatr Nephrol. 2007 Jul;22(7):1030-9. doi: 10.1007/s00467-007-0458-6. Epub 2007 Mar 20.

Reference Type BACKGROUND
PMID: 17372771 (View on PubMed)

Takken T, Engelbert R, van Bergen M, Groothoff J, Nauta J, van Hoeck K, Lilien M, Helders P. Six-minute walking test in children with ESRD: discrimination validity and construct validity. Pediatr Nephrol. 2009 Nov;24(11):2217-23. doi: 10.1007/s00467-009-1259-x. Epub 2009 Jul 25.

Reference Type BACKGROUND
PMID: 19633871 (View on PubMed)

Pattaragarn A, Warady BA, Sabath RJ. Exercise capacity in pediatric patients with end-stage renal disease. Perit Dial Int. 2004 May-Jun;24(3):274-80.

Reference Type BACKGROUND
PMID: 15185776 (View on PubMed)

Weaver DJ Jr, Kimball TR, Knilans T, Mays W, Knecht SK, Gerdes YM, Witt S, Glascock BJ, Kartal J, Khoury P, Mitsnefes MM. Decreased maximal aerobic capacity in pediatric chronic kidney disease. J Am Soc Nephrol. 2008 Mar;19(3):624-30. doi: 10.1681/ASN.2007070773. Epub 2008 Jan 9.

Reference Type BACKGROUND
PMID: 18184856 (View on PubMed)

Sethna CB, Salerno AE, McBride MG, Shults J, Paridon SM, Sharma N, Meyers KE, Leonard MB. Cardiorespiratory fitness in pediatric renal transplant recipients. Transplantation. 2009 Aug 15;88(3):395-401. doi: 10.1097/TP.0b013e3181aed7d1.

Reference Type BACKGROUND
PMID: 19667944 (View on PubMed)

Lammers AE, Hislop AA, Flynn Y, Haworth SG. The 6-minute walk test: normal values for children of 4-11 years of age. Arch Dis Child. 2008 Jun;93(6):464-8. doi: 10.1136/adc.2007.123653. Epub 2007 Aug 3.

Reference Type BACKGROUND
PMID: 17675356 (View on PubMed)

Enright PL. The six-minute walk test. Respir Care. 2003 Aug;48(8):783-5.

Reference Type BACKGROUND
PMID: 12890299 (View on PubMed)

Solway S, Brooks D, Lacasse Y, Thomas S. A qualitative systematic overview of the measurement properties of functional walk tests used in the cardiorespiratory domain. Chest. 2001 Jan;119(1):256-70. doi: 10.1378/chest.119.1.256.

Reference Type BACKGROUND
PMID: 11157613 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

6 minutes walk test

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Resistance Exercise in Hemodialysis Patients
NCT06604221 NOT_YET_RECRUITING NA