The Effects of Eccentric Compared to Standard Strength Training in Primary Spinal Cord Injury Rehabilitation

NCT ID: NCT06905470

Last Updated: 2025-12-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2026-03-01

Study Completion Date

2028-03-01

Brief Summary

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The goal of this clinical trial is to assess the effects of eccentric arm-crank (KREHA) training compared to standard clinical routine strength (STAN) training in individuals undergoing primary spinal cord injury (SCI) rehabilitation.

The main questions this trail aims to answer are:

* what are the effects of the training on upper body strength, aerobic performance, muscle volume, functional independence, and health-related quality of life?
* is the KREHA training feasible to implement into the rehabilitation routine?

Participants will:

* perform either 20 KREHA sessions or 20 STAN sessions within 12 weeks
* perform a test battery to collect data on training effects before (pretest) and after (posttest) the study intervention

Detailed Description

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Conditions

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Spinal Cord Injury

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Matched-pair randomized controlled trial
Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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Eccentric arm-crank (KREHA) training

The eccentric training intervention consists of 20 training sessions performed on a symmetric arm-crank (Krafttraining mittels exzentrischer Handkurbel, KREHA) device. The training sessions have a duration of approximately 30 min and will be completed within twelve weeks, with a maximum of three sessions per week.

Group Type EXPERIMENTAL

Eccentric (KREHA) training

Intervention Type PROCEDURE

20 eccentric resistance training sessions will be performed on a symmetric arm-crank ergometer in a supine position.

Standard clinical routine strength (STAN) training

The standard strength training intervention consists of a total of 20 training sessions at the gym of the study center, performed following clinical routine procedures. The training sessions have a duration of approximately 60 min and will be completed within twelve weeks, with around three sessions per week.

Group Type ACTIVE_COMPARATOR

Standard clinical routine strength (STAN) training

Intervention Type PROCEDURE

The regular strength training intervention consists of a total of 20 training sessions at the gym of the study center, performed following clinical routine procedures.

Interventions

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Eccentric (KREHA) training

20 eccentric resistance training sessions will be performed on a symmetric arm-crank ergometer in a supine position.

Intervention Type PROCEDURE

Standard clinical routine strength (STAN) training

The regular strength training intervention consists of a total of 20 training sessions at the gym of the study center, performed following clinical routine procedures.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* 18 years or older.
* informed consent as confirmed per signature.
* traumatic or disease-related SCI.
* participating in the routine strength training program during primary SCI rehabilitation at the study center (generally this is initiated around one month after SCI onset).
* wheelchair dependency during activities of daily living, defined by a score of 0-2 in the SCIM subsection regarding "Mobility in the house".
* passed sports medical assessment and having sufficient biceps/triceps function to perform arm-crank training, as determined by an experienced sports medicine physician

Exclusion Criteria

* inflammatory or neurodegenerative diseases (including multiple sclerosis or Guillain-Barré syndrome).
* comorbidities or other health issues that may interfere with study participation, inability or contraindications to undergo the investigated intervention.
* MRI contraindications (magnetic metal parts or electronic implants such as pacemakers in the body).
* pregnancy (anamnestic).
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Swiss Paraplegic Research, Nottwil

NETWORK

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Swiss Paraplegic Centre

Nottwil, Canton of Lucerne, Switzerland

Site Status

Countries

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Switzerland

Central Contacts

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Anneke Hertig-Godeschalk, PhD

Role: CONTACT

+414 9396603

Fabian Ammann, MSc

Role: CONTACT

+41419396624

Other Identifiers

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SNCTP000006132

Identifier Type: OTHER

Identifier Source: secondary_id

2023-21

Identifier Type: -

Identifier Source: org_study_id

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