Application of Plant Protection Products (PPP) in Apple Orchards

NCT ID: NCT06884189

Last Updated: 2025-03-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

16 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-03-11

Study Completion Date

2025-12-20

Brief Summary

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The aim of the aPPPle pilot study is to test feasibility and generate first results in preparation for a main study. The aPPPle study will investigate the exposure of operators, workers and residents to plant protection products (PPP) and potential physiological effects on blood biomarkers. The target plants are apple crops, as application occurs at higher altitudes and therefore higher drift/exposure is expected compared to ground-level application. The substances to be investigated are acetamiprid (an insecticide) and dithianon and dodine (two fungicides).

Detailed Description

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Conditions

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Dermal Exposure Inhalative Exposure Metabolites in Urine Effekt Biomarker in Blood

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Operators

People who apply plant protection products to apple crops.

No interventions assigned to this group

Workers

People who do manual work in apple cultivation, like pruning or harvesting.

No interventions assigned to this group

Residents

People whose place of residence is adjacent to the orchard under investigation.

No interventions assigned to this group

Control

People whose place of residence is at least 10 km away from agricultural apple orchards and a maximum of 150 km away from the apple orchard under investigation.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* belonging to one of the defined study groups
* over 18 years of age at the time of recruitment
* person can understand the language and content of the study requirements
* person is capable of consenting to participate in the study and has given written consent to participate in the aPPPle study
* person has health insurance

Exclusion Criteria

person has direct professional contact with the tested substances acetamiprid, dithianon or dodine
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Federal Ministry of Food and Agriculture

UNKNOWN

Sponsor Role collaborator

ESTEBURG Obstbauzentrum Jork Kompetenzzentrum für den norddeutschen Obstbau

UNKNOWN

Sponsor Role collaborator

German Federal Institute for Risk Assessment

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Federal Institute for Risk Assessment

Berlin, , Germany

Site Status RECRUITING

Countries

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Germany

Central Contacts

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Prof. Dr. Cornelia Weikert

Role: CONTACT

+49 301841255000

Dr. Anna Lechner

Role: CONTACT

+49 301841255015

Facility Contacts

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Prof. Dr. Cornelia Weikert

Role: primary

+49 301841255000

Other Identifiers

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02

Identifier Type: -

Identifier Source: org_study_id

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