Association Between Age-related Macular Degeneration and Cognitive Impairment Based on Exosome Proteomics
NCT ID: NCT06883461
Last Updated: 2025-03-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
120 participants
OBSERVATIONAL
2019-04-01
2024-06-03
Brief Summary
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Methods: Peripheral serum samples were collected from patients with AMD, MCI, comorbid conditions, and the control group. Exosomes were isolated from these samples and analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Differentially expressed proteins (DEPs) associated with the two diseases were identified based on fold change and p-value. DEPs were analyzed by Gene Ontology (GO) enrichment, Kyoto Encyclopedia of Genes and Genomes (KEGG), and protein-protein interaction (PPI) network analysis. Western blot and enzyme-linked immunosorbent assay (ELISA) were used to validate the DEPs of interest.
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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AMD
patients with only dry age-related macular degeneration
No interventions assigned to this group
MCI
patients with only mild cognitive impairment
No interventions assigned to this group
control
patients with no mild cognitive impairment and no age-related macular degeneration
No interventions assigned to this group
comorbid
patients with both mild cognitive impairment and dry age-related macular degeneration
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
All patients with MCI meet the Petersen criteria, including memory impairment, no abnormal cognitive function, dementia, or some cognitive impairment in daily life. A Mini-Mental State Examination (MMSE) score ≥24 points and a Montreal Cognitive Assessment (MoCA) score between 18 and 25 points were required.
40 Years
100 Years
ALL
Yes
Sponsors
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Shanghai 10th People's Hospital
OTHER
Responsible Party
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Sun Yilin
Training physician
Locations
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Shanghai Tenth People's Hospital
Shanghai, Shanghai Municipality, China
Countries
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Other Identifiers
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SHSY-IEC-4.1/156/01
Identifier Type: -
Identifier Source: org_study_id
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