Shanghai High Myopia Study for Adults

NCT ID: NCT03446300

Last Updated: 2018-02-26

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 2000 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2016-01-01
• Study Completion Date: 2020-12-31

Brief Summary

High myopia retinopathy has become the first cause of irreversible blindness and severe visual impairment in Chinese adults, in order to avoid the blind and visual impairment caused by high myopia retinopathy, it is very necessary to research the mechanism of early visual impairment to prevent and control damages. Our recent research found that the decreasing of macular retina vascular density and subfoveal choroidal thickness, the increasing of Beta Zone area in optic atrophy and the rising of glycosylated hemoglobin in high myopia patients were significantly related to visual impairment, which suggested that the source of visual impairment was the abnormal structure changes surrounding optic and fovea, but so far there is no related study. We will conduct a 5 years prospective cohort study in the population of 2420 high myopia and controls which have established in college student population, working population and aged more than 50 years old population, using the latest OCT-A and SS-OCT to measure macular retina vascular density, subfoveal choroidal thickness, Beta Zone area in optic atrophy, combined with the semiparametric mixed effects model, we will analysis the prediction index between fundus structure parameters, blood biochemical index and individual characteristics prediction to explore the public health management mode of early prevention and treatment during high myopia population.

Conditions

High Myopia

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

college student population

No interventions assigned to this group

working population

No interventions assigned to this group

aged more than 50 years old population

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• ≥18 years old; spherical equivalent refraction ≤-6.00D;

Exclusion Criteria

• a history of ocular or systemic diseases including congenital cataract and glaucoma; previous intraocular or refractive surgery;other evidence of retinal pathology

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 100 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Shanghai Eye Disease Prevention and Treatment Center

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Jianfeng Zhu, PhD, MD

Role: STUDY_DIRECTOR

Shanghai Eye Disease Prevention & Treatment Center

Locations

Shanghai Eye Disease Prevention & Treatment Center

Shanghai, Shanghai Municipality, China

Site Status: RECRUITING

Countries

China

Central Contacts

Xun Xu, MD

Role: CONTACT

drxuxun@tom.com

8613386259538

Facility Contacts

Xun Xu, MD

Role: primary

drxuxun@tom.com

86-13386259538

References

Li M, Xu H, Ye L, Zhou S, Xie J, Liu C, Zhu J, He J, Fan Y, Xu X. Association of macular outward scleral height with axial length, macular choroidal thickness and morphologic characteristics of the optic disc in Chinese adults. Eye (Lond). 2024 Apr;38(5):923-929. doi: 10.1038/s41433-023-02804-5. Epub 2023 Oct 28.

Reference Type: DERIVED

PMID: 37898715 (View on PubMed)

Other Identifiers

YFZX2018002

Identifier Type: -

Identifier Source: org_study_id