TAP Block , Intrathecal Morphine Or Their Combination For Post Operative Analgesia Following TAH

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

PHASE1

Total Enrollment

75 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-11-01

Study Completion Date

2025-07-31

Brief Summary

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This randomized controlled clinical trial designed to evaluate the efficacy of transversus abdominis plane (TAP) block, intrathecal morphine, or their combination in postoperative pain relief, as assessed by time to first analgesic request, pain scores, total postoperative analgesic consumption, time of ambulation, complications and hemodynamics following total abdominal hysterectomy.

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Detailed Description

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Conditions

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Post-operative Pain Management

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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TAP block

Bilateral ultrasound-guided TAP block with 20 mL of 0.25% plain bupivacaine on each side of the abdomen at the end of surgery.

Group Type ACTIVE_COMPARATOR

TAP Block

Intervention Type PROCEDURE

The transabdominal plane (TAP) block is a regional anesthesia technique used for postoperative pain management in abdominal wall procedures, providing somatic analgesia to the anterior and lateral abdominal walls

spinal anesthesia

Intervention Type DRUG

intrathecal injection of bupivacaine

Intrathecal Morphine

Intrathecal injection of 100 µg morphine plus 20 mg hyperbaric bupivacaine (in spinal anesthesia).

Group Type ACTIVE_COMPARATOR

Intrathecal morphine injection

Intervention Type DRUG

Intrathecal injection of morphine plus 20 mg hyperbaric bupivacaine in spinal anesthesia

spinal anesthesia

Intervention Type DRUG

intrathecal injection of bupivacaine

Combined

Intrathecal injection of 50 µg morphine plus 20 mg hyperbaric bupivacaine combined with bilateral ultrasound-guided TAP block using 20 mL of 0.25% plain bupivacaine on each side of the abdomen at the end of surgery.

Group Type ACTIVE_COMPARATOR

TAP Block

Intervention Type PROCEDURE

The transabdominal plane (TAP) block is a regional anesthesia technique used for postoperative pain management in abdominal wall procedures, providing somatic analgesia to the anterior and lateral abdominal walls

Intrathecal morphine injection

Intervention Type DRUG

Intrathecal injection of morphine plus 20 mg hyperbaric bupivacaine in spinal anesthesia

spinal anesthesia

Intervention Type DRUG

intrathecal injection of bupivacaine

Interventions

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TAP Block

The transabdominal plane (TAP) block is a regional anesthesia technique used for postoperative pain management in abdominal wall procedures, providing somatic analgesia to the anterior and lateral abdominal walls

Intervention Type PROCEDURE

Intrathecal morphine injection

Intrathecal injection of morphine plus 20 mg hyperbaric bupivacaine in spinal anesthesia

Intervention Type DRUG

spinal anesthesia

intrathecal injection of bupivacaine

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Female patients aged 30 to 70 years.
* Elective total abdominal hysterectomy.
* ASA physical status I or II.
* Willingness to provide informed consent.

Exclusion Criteria

* Refusal of the block.
* Allergy to study medications.
* Preexisting coagulation disorders.
* Local infection at the site of needle insertion.
* Uncontrolled respiratory or cardiac disorders.
* Impaired kidney or liver function.

Minimum Eligible Age

30 Years

Maximum Eligible Age

70 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes