Ultrasound Guided Rectus Sheath Block Versus Intrathecal Morphine for Postoperative Analgesia in Patients Undergoing Open Total Abdominal Hysterectomy

NCT ID: NCT06837506

Last Updated: 2025-02-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-02-20

Study Completion Date

2025-08-01

Brief Summary

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This study aims to compare the effectiveness and safety of ultrasound-guided rectus sheath block versus intrathecal morphine for postoperative analgesia in patients undergoing open total abdominal hysterectomy.

Detailed Description

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Effective postoperative analgesia is crucial for enhancing recovery and patient satisfaction following major surgical procedures, such as total abdominal hysterectomy (TAH).

Rectus sheath block (RSB), an ultrasound-guided regional anesthesia technique, involves the injection of local anesthetic into the rectus sheath, providing analgesia to the anterior abdominal wall. RSB is used to block the sensory nerves of the anterior abdominal wall and thereby contributing to pain relief after lower abdominal surgeries.

Intrathecal morphine (ITM) provides a highly effective method of analgesia by delivering the medication directly into the cerebrospinal fluid (CSF).

Conditions

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Ultrasound Rectus Sheath Block Intrathecal Morphine Postoperative Analgesia Total Abdominal Hysterectomy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Rectus sheath block group

Patients will receive rectus sheath block (20 ml bilaterally, bupivacaine 0.25%) after induction of general anesthesia.

Group Type EXPERIMENTAL

Rectus sheath block

Intervention Type DRUG

Patients will receive rectus sheath block (20 ml bilaterally, bupivacaine 0.25%) after induction of general anesthesia.

Intrathecal morphine group

Patients will receive 150 µg intrathecal morphine after induction of general anesthesia.

Group Type EXPERIMENTAL

Intrathecal morphine

Intervention Type DRUG

Patients will receive 150 µg intrathecal morphine after induction of general anesthesia.

Interventions

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Rectus sheath block

Patients will receive rectus sheath block (20 ml bilaterally, bupivacaine 0.25%) after induction of general anesthesia.

Intervention Type DRUG

Intrathecal morphine

Patients will receive 150 µg intrathecal morphine after induction of general anesthesia.

Intervention Type DRUG

Other Intervention Names

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Bupivacaine 0.25%

Eligibility Criteria

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Inclusion Criteria

* Age: 18 - 65 years old.
* American Society of Anesthesiologists (ASA) physical status (I -II).
* Patients undergoing open total abdominal hysterectomy.

Exclusion Criteria

* Hepatic, renal, or cardiac disease.
* Any known allergy to local anesthetic.
* Physical or mental conditions which may vague measuring postoperative pain following surgery.
* History of chronic use of analgesic as nonsteroidal anti-inflammatory drugs (NSAIDs) or central nervous system (CNS) depressants as antiepileptic, and bleeding disorders.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Ain Shams University

OTHER

Sponsor Role lead

Responsible Party

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Sarah Ahmed

Lecturer of Anesthesia, Intensive care, and pain management, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Ain Shams University

Cairo, , Egypt

Site Status RECRUITING

Countries

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Egypt

Central Contacts

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Sarah A Afifi, MD

Role: CONTACT

0501035864

Facility Contacts

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Sarah A Afifi, MD

Role: primary

0501035864

Other Identifiers

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FMASU R03/2024/2025

Identifier Type: -

Identifier Source: org_study_id

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