Psychotropic-Drug-induced QT Prolongation and ECG Monitoring in the Pediatric Population

NCT ID: NCT06870006

Last Updated: 2025-03-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-01-01

Study Completion Date

2027-01-31

Brief Summary

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Electrocardiogram (ECG) Q-T prolongation is a cardiac electrophysiological disorder associated with the occurrence of arrhythmias potentially fatal. Several psychotropic drugs are associated with an increased risk of QT prolongation, which is why in clinical practice a baseline ECG is performed before a psychotropic drug is prescribed. However, there are no validated protocols establishing when to repeat this examination or describing clinical events when this examination should be repeated in clinical follow-up.

The study aims to investigate the incidence of QTc prolongation events as a side effect of chronic psychotropic drug administration. For this purpose, ECGs will be recorded and confounding factors of patients at the beginning of psychotropic therapy and after 3, 6 and 12 months will be analyzed.

Detailed Description

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Conditions

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Eating Disorders Mood Disorders in Children and Adolescents Psychotic Disorder QTc Intervals Changes

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Monotherapy

Patients taking only one drug acting on QT interval

No interventions assigned to this group

Monotherapy to monotherapy

Patients who have switched from a drug acting on QT interval to another

No interventions assigned to this group

Polytherapy

Patients taking more than one drug acting on QT interval

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Admitted to psychiatry ward
* Starting a psychotropic drug acting on QT interval

Exclusion Criteria

* Age \>18aa
* History of administration of drug acting on QT interval in the 3 months prior
Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Meyer Children's Hospital IRCCS

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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AOU Meyer IRCCS

Florence, FI, Italy

Site Status RECRUITING

Countries

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Italy

Central Contacts

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Tiziana Pisano, MD

Role: CONTACT

3498705830 ext. +39

Facility Contacts

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Tiziana Pisano, MD

Role: primary

3498705830

Other Identifiers

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PDP-QT

Identifier Type: -

Identifier Source: org_study_id

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