Comparison Between Epinephrine and Exercise Test in QT Long Syndrome Patients
NCT ID: NCT01745666
Last Updated: 2016-10-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
130 participants
INTERVENTIONAL
2012-05-31
2018-05-31
Brief Summary
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Detailed Description
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All patients will have the 2 tests: exercise test and epinephrine test, in one half day.
At the end of the inclusions, two experts will examine examens results without knowing in which arm (mutated or not) the patient belongs.
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
DIAGNOSTIC
NONE
Study Groups
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patients with KCNQ1 or KCNH2 mutation
exercise test
Exercise test : Bruce protocol : exercise during 7 minutes, and rest during 6 minutes with registering of the electrocardiograms.
Epinephrine test
Epinephrine test : 1 hour after exercise test : epinephrine infusion during 20 minutes, and monitoring during 30 minutes after stop infusion with registering of electrocardiograms.
patients WITHOUT KCNQ1 or KCNH2 mutation (control group)
exercise test
Exercise test : Bruce protocol : exercise during 7 minutes, and rest during 6 minutes with registering of the electrocardiograms.
Epinephrine test
Epinephrine test : 1 hour after exercise test : epinephrine infusion during 20 minutes, and monitoring during 30 minutes after stop infusion with registering of electrocardiograms.
Interventions
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exercise test
Exercise test : Bruce protocol : exercise during 7 minutes, and rest during 6 minutes with registering of the electrocardiograms.
Epinephrine test
Epinephrine test : 1 hour after exercise test : epinephrine infusion during 20 minutes, and monitoring during 30 minutes after stop infusion with registering of electrocardiograms.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Treatment interfering with cardiac repolarisation
* Under 15 years old
* Pregnant women
* Contraindication to exercise or epinephrine tests
* Patients without social coverage
15 Years
ALL
Yes
Sponsors
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Nantes University Hospital
OTHER
Responsible Party
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Locations
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Bordeaux Universitary Hospital
Bordeaux, , France
Marseille Universitary Hospital
Marseille, , France
CHU Montpellier
Montpellier, , France
Nantes Universitary Hospital
Nantes, , France
Rennes Universitary Hospital
Rennes, , France
CHU Rouen
Rouen, , France
CHU Toulouse
Toulouse, , France
CHU Tours
Tours, , France
Countries
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Central Contacts
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Eric DELANNOY, PH
Role: CONTACT
Facility Contacts
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Other Identifiers
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RC11_0160
Identifier Type: -
Identifier Source: org_study_id
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