Use of Antiarrhythmic Drugs in Pediatrics

NCT ID: NCT04863001

Last Updated: 2021-05-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-10-01

Study Completion Date

2022-10-01

Brief Summary

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This study aims to describe the use of Cardiovascular Drugs in Pediatrics Cardiology unit Assiut University. As regard :

* indications of use .
* proper dosage.
* proper management of side effects of their use.

Detailed Description

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Arrhythmias occur in children and adolescents with congenital heart disease as well as those with structurally normal hearts. Antiarrhythmic medications primarily affect the ion channels in cardiac myocytes that are responsible for generating currents that create the action potential.

By altering the activity of these ion channels, the action potential is changed in an attempt to reduce the likelihood of sustained arrhythmias. There is awide range of antiarrhysmic drugs used in treatment Antiarrhysmics are therefore divided into five classes

Class I: Antiarrhythmics that affect sodium channels (slow depolarization) Class II: Drugs that counteract the sympathetic nervous system, predominantly beta-blockers Class III: drugs that affect the potasium channels ( prolong repolarization) Class IV: Drugs that affect calcium channels (Calcium channel blockers) Class V: Vagotonic drugs (Digoxin) and other miscellaneous drugs

Conditions

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Antiarrhythmic Toxicity

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Interventions

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Antiarrhythmic drug

all classes of antiarrhythmic drugs used in pediatrics cardiology unit assiut university

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* All Patients with Arrhythmic cardiac diseases admitted at cardiology unit Assiut University Hospital aged from 1 month to 18 years

Exclusion Criteria

* ● Patients with diseases rather than arrhythmic cardiac diseases
Minimum Eligible Age

1 Month

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Assiut University

OTHER

Sponsor Role lead

Responsible Party

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Areej Tarek Mostafa mohamed makhlouf

Principle investegator , Areej Tarek Mostafa

Responsibility Role PRINCIPAL_INVESTIGATOR

Central Contacts

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Areej makhlouf

Role: CONTACT

01001153846

Salah Eldin Ahmad

Role: CONTACT

References

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Podrid PJ. Antiarrhythmic drug selection. Annu Rev Med. 1987;38:1-17. doi: 10.1146/annurev.me.38.020187.000245.

Reference Type BACKGROUND
PMID: 3555284 (View on PubMed)

Other Identifiers

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antiarrhythmic drugs in pediat

Identifier Type: -

Identifier Source: org_study_id

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