Analysis of Cardiac Biomarkers, ECG and CPET Results in Children With Cardiomyopathies

NCT ID: NCT04316923

Last Updated: 2022-08-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

80 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-03-01

Study Completion Date

2024-03-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The aim of the study is to analyze cardiac biomarkers, electrocardiograms and cardio-pulmonary exercise test (CPET) results in children with cardiomyopathies.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The study group will consist of children that have been diagnosed with DCM, HCM or LVNC. The control group will be composed of healthy children. Examination of cardiac biomarkers (in the study group), ECG, 24-hour- ECG monitoring, CPET will be performed.

Patients in the study group will be invited for 2 consecutive visits (in 6-10 months intervals). During the first and the last visit CPET will be performed. The control group will not be invited for consecutive visits.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Cardiomyopathies

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Children with cardiomyopathies

Children aged 0-18 years that have been diagnosed with DCM, HCM or LVNC on the basis of a two-dimensional echocardiography with color Doppler.

ECG

Intervention Type DIAGNOSTIC_TEST

ECG will be performed during each visit in the study group.

24-hour ECG monitoring

Intervention Type DIAGNOSTIC_TEST

24-hour ECG monitoring will be performed during each visit in the study group.

Cardio-pulmonary exercise test (CPET)

Intervention Type DIAGNOSTIC_TEST

CPET will be performed during the first and the last visit in the study group.

Cardiac biomarkers

Intervention Type DIAGNOSTIC_TEST

Cardiac biomarkers will be assessed during each visit in the study group.

Healthy children

The control group will be composed of healthy children, in whom heart disease will be excluded using echocardiography.

ECG

Intervention Type DIAGNOSTIC_TEST

ECG will be performed during each visit in the study group.

24-hour ECG monitoring

Intervention Type DIAGNOSTIC_TEST

24-hour ECG monitoring will be performed during each visit in the study group.

Cardio-pulmonary exercise test (CPET)

Intervention Type DIAGNOSTIC_TEST

CPET will be performed during the first and the last visit in the study group.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

ECG

ECG will be performed during each visit in the study group.

Intervention Type DIAGNOSTIC_TEST

24-hour ECG monitoring

24-hour ECG monitoring will be performed during each visit in the study group.

Intervention Type DIAGNOSTIC_TEST

Cardio-pulmonary exercise test (CPET)

CPET will be performed during the first and the last visit in the study group.

Intervention Type DIAGNOSTIC_TEST

Cardiac biomarkers

Cardiac biomarkers will be assessed during each visit in the study group.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Children with HCM, DCM, LVNC diagnosed in 2D echo.
* Healthy children with no congenital heart disease (CHD) in 2D echo.
* Patients who signed consent form.

Exclusion Criteria

* Patients with coexisting CHD, kidney and liver disfunction, taking anti-psychotic and anti-depressant medication, or patients with bundle bunch blocks in ECG.
* no consent form signed.
Minimum Eligible Age

1 Day

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Katarzyna Łuczak-Woźniak

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Katarzyna Łuczak-Woźniak

MD, Department of Pediatric Cardiology and General Pediatrics, Medical University of Warsaw, Warsaw, Poland.

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Katarzyna M Luczak-Wozniak, MD

Role: PRINCIPAL_INVESTIGATOR

Medical Univeristy of Warsaw, Poland

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Medical Univeristy of Warsaw

Warsaw, , Poland

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Poland

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

WUM CM

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.