Influence of Food Texture on Appetite Control, Gastric Emptying, and Energy Expenditure

NCT ID: NCT06853249

Last Updated: 2025-04-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-04-30

Study Completion Date

2026-03-31

Brief Summary

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The aim of the study is to investigate the effect of liquid versus semi-solid meals on the regulation of energy balance in healthy young adults.The main questions it aims to answer are:

* Does a protein-rich liquid meal result in less satiety and therefore higher ad libitum energy intake at the next meal than an isocaloric oatmeal with the same macronutrient ratio?
* Is the consumption of a protein-rich liquid meal as a beverage in addition to an ad libitum oatmeal less compensated within the meal and at the next meal and provides thus a higher ad libitum energy intake than an isovolumetric noncaloric soft drink in addition to an ad libitum oatmeal?

Researchers will compare a protein-rich liquid meal to an isocaloric oatmeal with matched macronutrient composition to answer the first question. Researchers will compare a protein-rich liquid meal + oatmeal to a noncaloric softdrink (water with sucralose and flavoring) + oatmeal to answer the second question.

Participants will:

* spend 4 intervention days in a metabolic chamber (whole room indirect calorimeter)
* consume pre-definied preloads for breakfast and ad libitum lunch meals on 4 intervention days

Detailed Description

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Conditions

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Nutrition Healthy Male and Female Subjects

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

The trial consists of two arms, each with two interventions. All participants will receive all interventions.
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants
Blinding of participants to the actual primary outcome parameters to avoid energy intake bias

Study Groups

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isocaloric preload

In this arm of the study, participants receive two different isocaloric preloads for breakfast, one as a liquid meal and one as oatmeal.

Group Type EXPERIMENTAL

liquid meal

Intervention Type OTHER

An isocaloric amount (500 kcal) of a commercially available liquid meal with a matched macronutrient composition is consumed. After 5 hours, lunch is eaten ad libitum.

semi-solid meal

Intervention Type OTHER

An isocaloric amount (500 kcal) of a commercially available semi-solid oatmeal with a matched macronutrient composition is consumed. After 5 hours, lunch is eaten ad libitum.

ad libitum preload

In this arm of the study, participants are given two different isovolumetric drinks as a preload in addition to an ad libitum oatmeal breakfast. One drink is a liquid meal, the other is a non-caloric soft drink (water, sucralose, flavour).

Group Type EXPERIMENTAL

caloric drink + semi-solid meal

Intervention Type OTHER

A predefined amount of a caloric drink (= liquid meal) together with an ad libitum amount of a semi-solid meal is consumed. After 5 hours, lunch is eaten ad libitum.

non-caloric drink + semi-solid meal

Intervention Type OTHER

A predefined amount of a non-caloric drink (= water, sucralose, flavor) together with an ad libitum amount of a semi-solid meal is consumed. After 5 hours, lunch is eaten ad libitum.

Interventions

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liquid meal

An isocaloric amount (500 kcal) of a commercially available liquid meal with a matched macronutrient composition is consumed. After 5 hours, lunch is eaten ad libitum.

Intervention Type OTHER

semi-solid meal

An isocaloric amount (500 kcal) of a commercially available semi-solid oatmeal with a matched macronutrient composition is consumed. After 5 hours, lunch is eaten ad libitum.

Intervention Type OTHER

caloric drink + semi-solid meal

A predefined amount of a caloric drink (= liquid meal) together with an ad libitum amount of a semi-solid meal is consumed. After 5 hours, lunch is eaten ad libitum.

Intervention Type OTHER

non-caloric drink + semi-solid meal

A predefined amount of a non-caloric drink (= water, sucralose, flavor) together with an ad libitum amount of a semi-solid meal is consumed. After 5 hours, lunch is eaten ad libitum.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* healthy males and females
* Body Mass Index between 19-35 kg/m2
* low to medium habitual physical activity
* women with regular menstrual cycle (during intervention in follicular phase)

Exclusion Criteria

* smoking (cigarettes + cannabis)
* chronic illnesses
* regular intake of medication
* Anemia and/or iron deficiency
* food allergies / intolerances
* vegans
* regular high physical activity (exercise \>1 hour/d)
* current weight loss diet / weight loss of \>5 kg in the last 3 months
* restraint eaters (according to the German version of the 'Three-Factor-Eating-Questionnaire', Stunkard und Messick (1985))
* active participation in another trial
* pregnant / lactating women
* persons incapable of giving informed legal consent
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Kiel

OTHER

Sponsor Role lead

Responsible Party

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Prof. Dr. Dr. Anja Bosy-Westphal

Principal Investigator, Head of Department of Human Nutrition

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Anja Bosy-Westphal, PhD, MD

Role: PRINCIPAL_INVESTIGATOR

University of Kiel, Department of Human Nutrition

Locations

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Kiel University, Institute of Human Nutrition

Kiel, , Germany

Site Status RECRUITING

Countries

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Germany

Central Contacts

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Anja Bosy-Westphal, PhD, MD

Role: CONTACT

+494318805674

Facility Contacts

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Anja Bosy-Westphal, PhD, MD

Role: primary

+494318805674

Other Identifiers

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ABW-2025-YF

Identifier Type: -

Identifier Source: org_study_id

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