Association Between ΜFR and CABG Outcomes

NCT ID: NCT06844721

Last Updated: 2025-02-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

945 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-01-01

Study Completion Date

2026-12-31

Brief Summary

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The goal of this observational study is to evaluate the association between Murray law-based quantitative flow reserve and outcomes after coronary artery bypass graft surgery.

Detailed Description

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The goal of this observational study is to evaluate the association between Murray law-based quantitative flow reserve and outcomes after coronary artery bypass graft surgery. By constructing registry database during 10-year periods, several types of study objectives including 'graft patency' and 'long-term clinical outcomes' will be evaluated.

Conditions

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Coronary Artery Bypass Graft Surgery (CABG)

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

1. patients who underwent isolated off-pump CABG for 3-vessel disease,
2. patients who underwent preoperative coronary angiography that fits for μFR analysis,

Exclusion Criteria

1. Patients who underwent on-pump CABG
2. Patients in whom quality of preoperative coronary angiography did not fit for μFR analysis
Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Shanghai Jiao Tong University School of Medicine

OTHER

Sponsor Role collaborator

Seoul National University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Ho Young Hwang

professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Seoul National University Hospital

Seoul, , South Korea

Site Status

Countries

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South Korea

References

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Kotoku N, Ninomiya K, Ding D, O'Leary N, Tobe A, Miyashita K, Masuda S, Kageyama S, Garg S, Leipsic JA, Mushtaq S, Andreini D, Tanaka K, de Mey J, Wijns W, Tu S, Piazza N, Onuma Y, Serruys PW. Murray law-based quantitative flow ratio to assess left main bifurcation stenosis: selecting the angiographic projection matters. Int J Cardiovasc Imaging. 2024 Jan;40(1):195-206. doi: 10.1007/s10554-023-02974-z. Epub 2023 Oct 23.

Reference Type BACKGROUND
PMID: 37870715 (View on PubMed)

Tu S, Ding D, Chang Y, Li C, Wijns W, Xu B. Diagnostic accuracy of quantitative flow ratio for assessment of coronary stenosis significance from a single angiographic view: A novel method based on bifurcation fractal law. Catheter Cardiovasc Interv. 2021 May 1;97 Suppl 2:1040-1047. doi: 10.1002/ccd.29592. Epub 2021 Mar 4.

Reference Type BACKGROUND
PMID: 33660921 (View on PubMed)

Tonino PA, De Bruyne B, Pijls NH, Siebert U, Ikeno F, van' t Veer M, Klauss V, Manoharan G, Engstrom T, Oldroyd KG, Ver Lee PN, MacCarthy PA, Fearon WF; FAME Study Investigators. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N Engl J Med. 2009 Jan 15;360(3):213-24. doi: 10.1056/NEJMoa0807611.

Reference Type BACKGROUND
PMID: 19144937 (View on PubMed)

Pijls NH, van Schaardenburgh P, Manoharan G, Boersma E, Bech JW, van't Veer M, Bar F, Hoorntje J, Koolen J, Wijns W, de Bruyne B. Percutaneous coronary intervention of functionally nonsignificant stenosis: 5-year follow-up of the DEFER Study. J Am Coll Cardiol. 2007 May 29;49(21):2105-11. doi: 10.1016/j.jacc.2007.01.087. Epub 2007 May 17.

Reference Type BACKGROUND
PMID: 17531660 (View on PubMed)

Hwang HY, Ding D, Kang J, Sun P, Sohn SH, Tu S, Koo BK. Association Between Angiography-Derived Murray Law-Based Quantitative Flow Ratio and 1-Year Coronary Artery Bypass Graft Patency. JACC Cardiovasc Interv. 2025 Oct 13;18(19):2326-2334. doi: 10.1016/j.jcin.2025.08.027.

Reference Type DERIVED
PMID: 41093449 (View on PubMed)

Other Identifiers

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H-2212-151-1390

Identifier Type: -

Identifier Source: org_study_id

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