Cohort Study Evaluating Glycaemic Control in Individuals with Type 2 Diabetes Mellitus Through Digital Therapeutics (DM DTx)

NCT ID: NCT06810986

Last Updated: 2025-02-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

500 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-08-20

Study Completion Date

2025-07-31

Brief Summary

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This study is conducted to evaluate the effectiveness of Digital therapeutics (DTx) in managing patients with Type 2 Diabetes Mellitus (T2DM) by delivering digital lifestyle interventions through a national health application (BruHealth).

Detailed Description

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This study is a single-arm, non-randomised clinical trial designed to evaluate the effectiveness and feasibility of an online management approach to improve glycaemic control in individuals with Type 2 Diabetes Mellitus (T2DM) through a digital lifestyle intervention (named the BALANCE Programme) over a 16-week period. The intervention leverages the Diabetes Mellitus Digital Therapeutics (DM DTx) module within the BruHealth application. Additionally, a Healthcare Professional (HCP) portal is included to facilitate ongoing monitoring and support, ensuring personalized care and real-time interactions between participants and healthcare providers.

In addition, Muslim participants are offered the option of providing information in the DM DTx module about their fasting practices during Ramadan as an opportunistic way of obtaining data on the fasting risk and fasting experience in this cohort.

Primary Objective:

The primary objective is to assess the proportion of participants who experience a reduction in HbA1c levels by at least 0.6% by the end of the 16-week intervention period.

Secondary Objectives:

1. To evaluate the overall changes in HbA1c, fasting blood glucose, Body Mass Index (BMI), waist circumference and improvements in lipid profile components (such as cholesterol and triglycerides) at week 16, compared to baseline measurements;
2. To evaluate participants' feedback on their experience with the BALANCE Programme and its usability after 16 weeks of usage;
3. to evaluate fasting experience amongst Muslims with T2DM during Ramadhan and to calculate their fasting risk using IDF-DAR score.

Conditions

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Type 2 Diabetes Mellitus (T2DM)

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

NONE

Study Groups

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Digital Therapeutics for Type 2 Diabetes Mellitus

16 weeks digital intervention with online support

This study is a single-arm, non-randomised clinical trial, which will collect participant's baseline data, apply relevant assessment scales, collect data using a comprehensive digital intervention in 16 weeks to evaluate the improvement of relevant markers post intervention.

Group Type EXPERIMENTAL

16-week digital intervention

Intervention Type BEHAVIORAL

Participants will be enrolled in a 16-week programme with the aim to manage T2DM through lifestyle adjustments. Participants will be given online support by their personal health coach with additional support from a dietitian or clinician in the study if required.

Each participant will receive personalised recommendations for blood glucose monitoring schedule, diet and physical activity. Participants are required to log their blood glucose, diet and physical activity in the BruHealth application. Participants will review their progress with their health coach via video consultation on a regular basis. Additionally, participants will also participate in a structured diabetes self-management education course.

Interventions

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16-week digital intervention

Participants will be enrolled in a 16-week programme with the aim to manage T2DM through lifestyle adjustments. Participants will be given online support by their personal health coach with additional support from a dietitian or clinician in the study if required.

Each participant will receive personalised recommendations for blood glucose monitoring schedule, diet and physical activity. Participants are required to log their blood glucose, diet and physical activity in the BruHealth application. Participants will review their progress with their health coach via video consultation on a regular basis. Additionally, participants will also participate in a structured diabetes self-management education course.

Intervention Type BEHAVIORAL

Other Intervention Names

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Lifestyle Intervention

Eligibility Criteria

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Inclusion Criteria

* Age 18 to 70 years
* Diagnosed with T2DM who are on any one or more of the following treatments:

1. oral glucose lowering medication(s)
2. any type of insulin treatment (up to 2 injections a day only)
3. on diet control only
4. GLP-1 receptor agonist established at least 6 months prior to enrolment

Exclusion Criteria

* Diagnosed with T2DM on more than 2 insulin injections a day
* Diagnosed with Type 1 Diabetes Mellitus (T1DM)
* Pregnant / Breast-feeding
* Recent Myocardial Infarction (MI) or Stroke / Cerebrovascular Accidents (CVA) in the past 6 months
* Heart failure
* Liver failure
* Active cancer
* Undergoing active treatment for active foot disease
* Undergoing active treatment for active diabetes-related eye disease
* CKD stage 4 and 5 (eGFR \< 30ml/min)
* Hospitalisation for any reason in the past 6 months
* Advised by doctor to not participate in intense physical activity
* Physical disability and/or unable to perform Activities of Daily Living (ADL) independently
* Unable to use Youtube on mobile devices
* Unable to use BruHealth independently
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ministry of Health, Brunei Darussalam

UNKNOWN

Sponsor Role collaborator

EVYD Technology

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Chong Pui Lin, BM, MD

Role: PRINCIPAL_INVESTIGATOR

Raja Isteri Pengiran Anak Saleha (RIPAS) hospital

Locations

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EVYD Technology

Bandar Seri Begawan, , Brunei

Site Status RECRUITING

Countries

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Brunei

Central Contacts

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Jane Tey, Msc Immunology

Role: CONTACT

+673 7430790

Joshua Lam, MBBS

Role: CONTACT

+65 97309276

Facility Contacts

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Joshua Lam, MBBS

Role: primary

+65 97309276

Jane Tey, Msc Immunology

Role: backup

+673 7430790

Other Identifiers

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BALANCE Programme

Identifier Type: OTHER

Identifier Source: secondary_id

MHREC/MOH/2024/11

Identifier Type: -

Identifier Source: org_study_id

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