Development and Exploration of the Effectiveness and Feasbility of a Digital Intervention for Type 2 Diabetes Mellitus

NCT ID: NCT05364476

Last Updated: 2023-07-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

122 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-04-11

Study Completion Date

2023-04-28

Brief Summary

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The study is conducted to assess potential effectiveness and feasibility of a comprehensive digital intervention for people with poorly-controlled Type 2 Diabetes Mellitus (T2DM), to explore the intervention effects of a combined online and offline management for people with T2DM and ultimately to improve the accessibility of lifestyle intervention among participants with T2DM.

Detailed Description

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The study is a single-arm, non-randomized clinical trial conducted to assess potential effectiveness and feasibility of a comprehensive digital intervention for people with poorly-controlled T2DM, to explore the 16 weeks intervention effects of a combined online and offline management for people with T2DM and ultimately to improve the accessibility of lifestyle intervention among participants with T2DM.

Primary objective is to study the proportion of participants with decrease in Hba1c by 0.6% by providing digital based lifestyle modifications. Secondary objectives include to 1) estimate the change in Hba1c, body mass index (BMI) and improvement in lipid profile components at week 16 compared with baseline readings; 2) to evaluate of the use of the Ramadan Risk Score (IDF-DAR Risk Stratification Scoring Tool); 3) to evaluate the rate of fasting and diabetes complications (hyperglycaemia / hypoglycaemia) amongst Muslims with T2DM during Ramadan.

Conditions

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Diabetes Mellitus, Type II

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

This study is a single-arm, non-randomized clinical trial, which will collect participant's baseline data, apply relevant assessment scales, collect data using a comprehensive digital intervention in 16 weeks to evaluate the improvement of relevant markers post intervention.
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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16 weeks digital intervention with online and offline support

This study is a single-arm, non-randomized clinical trial, which will collect participant's baseline data, apply relevant assessment scales, collect data using a comprehensive digital intervention in 16 weeks to evaluate the improvement of relevant markers post intervention.

Group Type EXPERIMENTAL

16 weeks digital intervention

Intervention Type BEHAVIORAL

Participants will be enrolled into a 16-week program which consist of an online and offline support from health coaches and dietitian. Participants will be given diet and exercise recommendations and lesson plans on a weekly basis by the health coaches, and supported by the dietitian.

Participants will be required to log in their blood sugar levels, weight and steps daily using connected device, including glucometer, smart band and body fat weighing scale provided into the daily report card. They will also be required to manually record their meals and exercise daily in the daily report card provided upon enrollment into study. Reviews of log will be done on a weekly/biweekly interval by the health coaches.

Interventions

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16 weeks digital intervention

Participants will be enrolled into a 16-week program which consist of an online and offline support from health coaches and dietitian. Participants will be given diet and exercise recommendations and lesson plans on a weekly basis by the health coaches, and supported by the dietitian.

Participants will be required to log in their blood sugar levels, weight and steps daily using connected device, including glucometer, smart band and body fat weighing scale provided into the daily report card. They will also be required to manually record their meals and exercise daily in the daily report card provided upon enrollment into study. Reviews of log will be done on a weekly/biweekly interval by the health coaches.

Intervention Type BEHAVIORAL

Other Intervention Names

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lifestyle intervention

Eligibility Criteria

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Inclusion Criteria

* participants diagnosed with T2DM;
* HbA1c 7% and above in the latest blood test valid up to 12months prior to recruitment;
* age range between 20-70 years old;
* BMI between 23-50kg/m2

Exclusion Criteria

* Pregnant / Breast feeding participants
* Participants on insulin therapy or non-insulin injectable medication
* History of diabetes crisis (hyper or hypoglycaemia) in the past 6 months
* Blood pressure ≥ 160/100 mmHg
* Recurrent history of acute pancreatitis
* Decompensated liver cirrhosis
* eGFR \<60ml/min/1.73m2
* History of acute myocardial infarction/acute coronary syndrome(within the past 1 year), arrhythmias, heart failure (NY Class II -IV)
* Proliferative diabetic retinopathy-Foot ulcer, gangrene
* Deep vein thrombosis of lower limbs(within the past 12 months)
* Intermittent claudication -History of cerebral haemorrhage or acute cerebral infarction (within the past 12 months)
* History of active cancer
* Post-transplant/perioperative participants(defined as planned for operation for the next 6 months)
* History of hypo or hyperthyroidism, including subclinical states
* Musculoskeletal injuries resulting in difficulty to perform physical activities
* Failure to provide consent
* Unable to perform activities of daily livings (ADLs)
* Unable to use WhatsApp and YouTube via mobile devices, e.g. phone or tablet.
Minimum Eligible Age

20 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Raja Isteri Pengiran Anak Saleha Hospital

OTHER_GOV

Sponsor Role collaborator

EVYD Technology

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Alice Moi Ling Yong, MBBS

Role: PRINCIPAL_INVESTIGATOR

Raja Isteri Pengiran Anak Saleha Hospital (RIPAS) Hospital

Locations

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EVYD Technology Limited

Singapore, , Singapore

Site Status

Countries

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Singapore

References

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Chan HN, Lim HS, Chong PL, Yung CK, Abd Mulok M, Wei Y, Yong AML. Development and Exploration of the Effectiveness and Feasibility of a Digital Intervention for Type 2 Diabetes Mellitus (DEsireD): Protocol for a Clinical Nonrandomized Pilot Trial in Brunei Darussalam. JMIR Res Protoc. 2022 Dec 7;11(12):e43208. doi: 10.2196/43208.

Reference Type BACKGROUND
PMID: 36477014 (View on PubMed)

Related Links

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Other Identifiers

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MHREC/MOH/2022/4(1)

Identifier Type: -

Identifier Source: org_study_id

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