Sufentanil in Patients With Lower Extremity Fracture Surgery Myocardial Damage Function Study
NCT ID: NCT06808841
Last Updated: 2025-02-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
160 participants
INTERVENTIONAL
2025-02-05
2025-05-10
Brief Summary
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2. To observe the effect of different doses of opioids on the expression of BMP-6 in bone marrow.
3. To investigate the relationship between different doses of opioids and BMP-6 and perioperative cardiovascular adverse events in patients with lower extremity fracture surgery.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Low dose sufentanil group
The concentration of sufentanil is set to concentration for the low-dose group
Sufentanil injection
Different concentrations of sufentanil were administered to three different subgroups of patients in the same way
Medium-dose sufentanil group
The concentration of sufentanil is set to medium-dose concentration for the low-dose group
Sufentanil injection
Different concentrations of sufentanil were administered to three different subgroups of patients in the same way
High dose sufentanil group
The concentration of sufentanil is set to high concentration for the low-dose group
Sufentanil injection
Different concentrations of sufentanil were administered to three different subgroups of patients in the same way
Blank control group
No analgesics were given
Placebo
Placebo
Interventions
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Sufentanil injection
Different concentrations of sufentanil were administered to three different subgroups of patients in the same way
Placebo
Placebo
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* ASA grades I to III, gender is not limited.
Exclusion Criteria
* Old fracture
* Stroke patients
* Liver cirrhosis, kidney failure
* Serious systemic infections, alcoholism, drug dependence
* Pathological fracture
* Use of glucocorticoids in the past one month
* Diabetic
18 Years
65 Years
ALL
Yes
Sponsors
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Second Hospital of Shanxi Medical University
OTHER
Responsible Party
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Zheng Guo
Professor
Locations
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Second Hospital of Shanxi Medical University
Taiyuan, Shanxi, China
Countries
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Central Contacts
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Other Identifiers
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Gz20250110
Identifier Type: -
Identifier Source: org_study_id
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