Optimised Post-discharge Care in Older Patients After Surgery for Colon Cancer (ERAS 3.0)

NCT ID: NCT06802991

Last Updated: 2025-06-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-04-01

Study Completion Date

2029-12-20

Brief Summary

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The purpose of the study is to investigate whether an extended program (ERAS 3.0) initiated hospital discharge, can improve recovery in elderly, frail patients who have undergone surgery for colon cancer.

The study is a randomised controlled trial with two groups: an intervention group receiving the ERAS 3.0 program and a control group recieving standard care. The ERAS 3.0 program includes a comprehensive geriatric health assessment, dietary counseling from a dietitian, and instructions on training and physical activity. These activities will take place in the participant's homes after hospital discharge. Data will be collected at multiple time points: at the hospital, 12 days post-discharge (at the outpatient clinic), and at 1 and 3 months post discharge in the participants' homes.

Detailed Description

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Conditions

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Colon Cancer Frailty

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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ERAS 3.0 group

Post-surgery support at discharge and at home

Group Type EXPERIMENTAL

ERAS 3.0 (Enhanced Recovery After Surgery)

Intervention Type OTHER

Nutritional support at discharge and home visits which include comprehensive geriatric assessment, nutritional guidance by dietitian, and instructions on exercise and physical activity.

Standard care group

Standard care, which is no support after discharge

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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ERAS 3.0 (Enhanced Recovery After Surgery)

Nutritional support at discharge and home visits which include comprehensive geriatric assessment, nutritional guidance by dietitian, and instructions on exercise and physical activity.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age 65+
* Clinical Frailty Scale preoperative score 4-7
* Nutritional Risk Screening tool (NRS 2002) \> 3
* Elective colonic resection
* No stoma planned
* Minimally invasive surgical approach (laparoscopic or robotic)
* Patients discharged to own home
* Informed consent to participate

Exclusion Criteria

* Stoma creation during index surgery
* Conversion to laparotomy
* Major complications following surgery (Clavien-Dindo \>3a)
* Participation in other randomised trials in conflict with the protocol and end- points of the ERAS 3.0 project
* Discharged with tube feeding and parenteral nutrition (partially or completely)
* Known food allergies to dairy or any other ingredient contained in the nutrition package
* Incapable of providing informed consent
* Discharge to 24-hour municipal rehabilitation facility
* All conditions including psychological, geographical, and social factors that could hinder adherence to the trial protocol
* Neoadjuvant radio- or chemotherapy
Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Danish Cancer Society

OTHER

Sponsor Role collaborator

Copenhagen University Hospital at Herlev

OTHER

Sponsor Role lead

Responsible Party

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Elna A. Dalsgaard

MSc, ph.d. student

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jacob Rosenberg, Professor, dr. med.

Role: STUDY_DIRECTOR

Center of Perioperative Optimisation, Copenhagen University Hospital at Herlev

Locations

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University Hospital Herlev

Herlev, , Denmark

Site Status NOT_YET_RECRUITING

University Hospital Herlev

Herlev, , Denmark

Site Status RECRUITING

Countries

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Denmark

Central Contacts

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Elna A. Dalsgaard, ph.d. student

Role: CONTACT

+45 42402296

Jacob Rosenberg, Professor, dr.med.

Role: CONTACT

Facility Contacts

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Elna A. Dalsgaard, ph.d.-student

Role: primary

+45 42402296

Elna Dalsgaard

Role: primary

+45 42402296

References

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Munk T, Svendsen JA, Knudsen AW, Ostergaard TB, Thomsen T, Olesen SS, Rasmussen HH, Beck AM. A multimodal nutritional intervention after discharge improves quality of life and physical function in older patients - a randomized controlled trial. Clin Nutr. 2021 Nov;40(11):5500-5510. doi: 10.1016/j.clnu.2021.09.029. Epub 2021 Sep 24.

Reference Type BACKGROUND
PMID: 34656032 (View on PubMed)

Dolin TG, Mikkelsen M, Jakobsen HL, Nordentoft T, Pedersen TS, Vinther A, Zerahn B, Vistisen KK, Suetta C, Nielsen D, Johansen JS, Lund CM. Geriatric assessment and intervention in older vulnerable patients undergoing surgery for colorectal cancer: a protocol for a randomised controlled trial (GEPOC trial). BMC Geriatr. 2021 Jan 30;21(1):88. doi: 10.1186/s12877-021-02045-9.

Reference Type BACKGROUND
PMID: 33516195 (View on PubMed)

Other Identifiers

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H-24078496

Identifier Type: -

Identifier Source: org_study_id

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