Treatment of "Low Anterior Resection Syndrome" by Percutaneous Nerve Evaluation and Transanal Irrigation

NCT ID: NCT01313026

Last Updated: 2018-12-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

14 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-01-31

Study Completion Date

2018-09-30

Brief Summary

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A randomised trial testing the effect of percutaneous nerve evaluation and transanal irrigation on bowel function in patients after low anterior resection for rectal cancer.

Detailed Description

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Patients will undergo anal physiological assessment and will then be randomized to either treatment arm. The first 12 weeks they will be optimized in the conservative treatment of their bowel function before beginning active treatment with TAI or PNE. After 8 and 4 weeks respectively, the treatment will stop and they will have a period of 4 weeks back on optimized conservative treatment before beginning active treatment in the other active arm.

Detailed records of bowel, micturition and sexual function and QoL will be obtained at regular intervals during the entire trial fase.

Conditions

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Rectal Cancer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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PNE first

patients randomised to start with PNE stimulation over 4 weeks. Then the stimulator will be removed and after a wash out period of 4 weeks they will be trained in transanal irrigation

Group Type ACTIVE_COMPARATOR

Percutaneous nerve evaluation

Intervention Type PROCEDURE

Implantation of a nerve stimulator to stimulate the sacral nerve plexus

TAI first

Patients randomised to start with transanal irrigation treatment in 8 weeks, thereafter a wash out period of 4 weeks before being implanted with a neuro stimulator

Group Type ACTIVE_COMPARATOR

Percutaneous nerve evaluation

Intervention Type PROCEDURE

Implantation of a nerve stimulator to stimulate the sacral nerve plexus

Interventions

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Percutaneous nerve evaluation

Implantation of a nerve stimulator to stimulate the sacral nerve plexus

Intervention Type PROCEDURE

Other Intervention Names

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The Peristeen Anal Irrigation System Medtronic nerve stimulators

Eligibility Criteria

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Inclusion Criteria

* Low anterior resection for rectal cancer between May 2001 and May 2011

Exclusion Criteria

* Non-radical resection
* metastatic disease
* Chemotherapy
* Radiotherapy
* Previously treated for another cancer
* Dementia or other mental retardation/severe mental disease
* Inability to read and understand the Danish language
* Recurrent disease
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Aarhus

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Katrine J. Emmertsen, MD

Role: PRINCIPAL_INVESTIGATOR

University of Aarhus

Locations

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Colorectal Surgical Department P, Aarhus University Hospital

Aarhus, , Denmark

Site Status

Countries

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Denmark

Other Identifiers

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LARS 001

Identifier Type: -

Identifier Source: org_study_id

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