Cervical Preparation for Same-Day Dilation & Evacuation

NCT ID: NCT06799052

Last Updated: 2025-06-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

32 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-06-12

Study Completion Date

2026-09-30

Brief Summary

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This is a noninferiority randomized control trial of two cervical preparation methods prior to same-day Dilation \& Evacuation (D\&E). Cervical preparation is a process that softens and dilates the cervix prior to a procedure.

The primary objective is to evidence noninferiority of cervical preparation using a single-balloon catheter method when compared to a group receiving osmotic dilators, specifically in D\&E operative time.

Secondary objectives will compare the two methods for adequate dilation, ability to complete the operation in the same day, participant pain, satisfaction and safety.

Detailed Description

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Conditions

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Abortion, Second Trimester Procedural Pain Procedural Complication

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

This is a noninferiority parallel randomized control trial of two cervical preparation methods prior to same-day D\&E.
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Transcervical single-balloon catheter group

Participants randomized to this arm will have cervical dilation done using a transcervical single-balloon catheter.

Group Type EXPERIMENTAL

Transcervical single-balloon catheter

Intervention Type DEVICE

A single-balloon (Foley) catheter will be placed through the cervix and filled to 30cc of water or saline. The balloon will remain in the participant until their procedure, usually 3-4 hours, or earlier if it falls out on its own.

Osmotic dilators group

Participants randomized to this arm will have cervical dilation done using osmotic dilators.

Group Type ACTIVE_COMPARATOR

Synthetic osmotic dilators

Intervention Type DEVICE

Dilators will be maintained in the cervix between 3-4 hours, during which each dilator rod will swell several times its initial dried diameter.

Interventions

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Transcervical single-balloon catheter

A single-balloon (Foley) catheter will be placed through the cervix and filled to 30cc of water or saline. The balloon will remain in the participant until their procedure, usually 3-4 hours, or earlier if it falls out on its own.

Intervention Type DEVICE

Synthetic osmotic dilators

Dilators will be maintained in the cervix between 3-4 hours, during which each dilator rod will swell several times its initial dried diameter.

Intervention Type DEVICE

Other Intervention Names

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Foley catheter Dilapan-S, seaweed laminaria

Eligibility Criteria

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Inclusion Criteria

* Between 16 weeks 0 days - 18 weeks 6 days gestational age who are pursuing termination, based on reliable gestational age (defined as ultrasonography performed by a clinical provider, or a certain last menstrual period)
* Able to provide informed consent
* English- or Spanish-speaking
* Singleton intrauterine pregnancy

Exclusion Criteria

* Allergy to betadine, aquacryl hydrogel, latex-free silicone single-balloon catheter, synthetic or natural osmotic dilators
* Fetal demise or known fetal anomaly
* BMI \>45
* Incarceration or other inability to give informed consent
* Decide to undergo cervical preparation overnight prior to next-day D\&E
Minimum Eligible Age

16 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Boston Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Anjanique Mariquit Lu, MD

Role: PRINCIPAL_INVESTIGATOR

Boston Medical Center, Obstetrics and Gynecology

Locations

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Boston Medical Center

Boston, Massachusetts, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Anjanique Mariquit Lu, MD

Role: CONTACT

617 414 5716

Alana Martinusen, MPH

Role: CONTACT

617 383 3500

Facility Contacts

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Anjanique M Lu, MD

Role: primary

617-414-5716

Pauline Yang, BS

Role: backup

617 414 5716

Other Identifiers

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H-45533

Identifier Type: -

Identifier Source: org_study_id

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