Foley Catheter Versus Vaginal Misoprostol for Cervical Ripening and Induction of Labor

NCT ID: NCT01140971

Last Updated: 2010-06-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

180 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-01-31

Study Completion Date

2009-01-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

PURPOSE: The purpose of this study is to determine the effectiveness of balloon dilatation (Foley) with vaginal misoprostol for cervical ripening and induction of labor.

METHOD: a randomized clinical assay has been performed with 160 women with indication of induction of labor, randomly divided in two groups, 80 for Foley catheter and 80 for misoprostol.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The cesarean delivery rate has risen dramatically in almost all world. Brazil shows the highest rate in the world so we need urgently efforts to reduce this fact. Several studies have shown that maternal morbidity and mortality rates are higher in cesarean deliveries. On the other hand an abdominal delivery cost much more than a vaginal delivery.

A clinical trial to assess the performance of two simple and sheep methods can provide evidence based on local experience. Our results alow us to recommend both methods for clinical practice with a good possibility to reduce cesarean rates and without adverse events.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Pregnancy, Prolonged Pre Eclampsia Oligohydramnios

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Misoprostol

Use 25 micrograms vaginal every 6 hours (max dosis 200 micrograms in 48 hours)

Group Type ACTIVE_COMPARATOR

Misoprostol

Intervention Type DRUG

Vaginal application of 25 micrograms every 6 hours until cervical ripening reach Bishop 6 or more

Foley

Foley catheter number 14 or 16 was installed intracervical for no more than 48 hours.

Group Type ACTIVE_COMPARATOR

Foley

Intervention Type DEVICE

After Foley introduction, every 6 hours vaginal exam was performed. The cases on Bishop score increase or occurred spontaneous exit of catheter or spontaneous labour had been initiated are considered success.The failure was adopted if after48 hours occurred no cervical modifications.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Misoprostol

Vaginal application of 25 micrograms every 6 hours until cervical ripening reach Bishop 6 or more

Intervention Type DRUG

Foley

After Foley introduction, every 6 hours vaginal exam was performed. The cases on Bishop score increase or occurred spontaneous exit of catheter or spontaneous labour had been initiated are considered success.The failure was adopted if after48 hours occurred no cervical modifications.

Intervention Type DEVICE

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Prostokos 25 micrograms

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Gestational age from 37 weeks,
* feto unic, alive and cephalic,
* Bishop index equal or lesser than four.

Exclusion Criteria

* uterine scar,
* premature rupture of the membranes,
* fetal weight bigger than 4000 g,
* previous placenta,
* conditions that imposed the immediate ending of the gestation.
Minimum Eligible Age

19 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Municipal Hospital Vila Nova Cachoeirinha

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Maternidade Escola de Vila Nova Cachoeirinha

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Nelson Sass, pHD

Role: PRINCIPAL_INVESTIGATOR

Maternidade Escola de Vila Nova Cachoeirinha

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

MHVNCachoeirinha

São Paulo, São Paulo, Brazil

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Brazil

References

Explore related publications, articles, or registry entries linked to this study.

Sciscione AC, Muench M, Pollock M, Jenkins TM, Tildon-Burton J, Colmorgen GH. Transcervical Foley catheter for preinduction cervical ripening in an outpatient versus inpatient setting. Obstet Gynecol. 2001 Nov;98(5 Pt 1):751-6. doi: 10.1016/s0029-7844(01)01579-4.

Reference Type BACKGROUND
PMID: 11704164 (View on PubMed)

Afolabi BB, Oyeneyin OL, Ogedengbe OK. Intravaginal misoprostol versus Foley catheter for cervical ripening and induction of labor. Int J Gynaecol Obstet. 2005 Jun;89(3):263-7. doi: 10.1016/j.ijgo.2005.02.010. Epub 2005 Apr 2.

Reference Type BACKGROUND
PMID: 15919393 (View on PubMed)

Boulvain M, Kelly A, Lohse C, Stan C, Irion O. Mechanical methods for induction of labour. Cochrane Database Syst Rev. 2001;(4):CD001233. doi: 10.1002/14651858.CD001233.

Reference Type BACKGROUND
PMID: 11687101 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

MHVNCachoeirinha

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Combined Method for Induction of Labor
NCT02685085 UNKNOWN PHASE2
Foley Catheter Induction
NCT05257187 WITHDRAWN NA
Outpatient Foley Cervix Priming
NCT02842879 COMPLETED NA