A Randomized Trial of Induction Methods in Premature Rupture of Membranes

NCT ID: NCT03744078

Last Updated: 2018-11-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-04-15

Study Completion Date

2019-01-01

Brief Summary

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This study evaluates the addition of transcervical Foley catheter balloon and vaginal prostaglandin E2 induction in premature rupture of membranes. Half of participants will be used combine transcervical Foley catheter balloon and vaginal prostaglandin E2, while the other half will be used alone vaginal prostaglandin E2.

Detailed Description

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Conditions

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Preterm Premature Rupture of Fetal Membranes Induction of Labor Affected Fetus / Newborn

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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PGE2 with Foley balloon catheter

10 mg PGE2 vaginal ovul will be inserted to the posterior fornix and an 18-F Foley catheter which filling with 60 mL of saline solution will be placed into the cervix

Group Type ACTIVE_COMPARATOR

Foley balloon catheter

Intervention Type DEVICE

18-F Foley catheter which filling with 60 mL of saline solution will be placed into the cervix

PGE2 vaginal ovule

10 mg PGE2 vaginal ovule will be inserted to the posterior fornix

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Foley balloon catheter

18-F Foley catheter which filling with 60 mL of saline solution will be placed into the cervix

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. singleton pregnancy,
2. gestational age ≥34 weeks,
3. rupture of membranes,
4. cephalic presentation,
5. bishop score ≤5,
6. had less than three uterine contractions in every 10 minutes.

Exclusion Criteria

1. Patients who had contraindications for vaginal delivery,
2. previous uterine surgery,
3. fetal malpresentation,
4. multifetal pregnancy,
5. more than three contractions in 10 minutes,
6. contraindications to prostaglandins,
7. a category II or III fetal heart rate pattern,
8. anomalous fetus,
9. fetal demise
10. women with immediate delivery indications -
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Zeynep Kamil Maternity and Pediatric Research and Training Hospital

OTHER

Sponsor Role lead

Responsible Party

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Ahmet Eser

M.D.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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ahmet eser

Role: STUDY_DIRECTOR

Zeynep Kamil Maternity and Children's Training and Research Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey

Locations

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Doga

Istanbul, Kucukcekmece, Turkey (Türkiye)

Site Status RECRUITING

Zeynep Kamil Education and Research Hospital

Istanbul, Uskudar, Turkey (Türkiye)

Site Status RECRUITING

Countries

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Turkey (Türkiye)

Central Contacts

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ahmet eser

Role: CONTACT

905067136880

and yavuz

Role: CONTACT

905062224075

Facility Contacts

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Doga Seckin

Role: primary

905065152715

Doga Seckin

Role: backup

ahmet eser

Role: primary

905067136880

ahmet eser

Role: backup

References

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de Vaan MD, Ten Eikelder ML, Jozwiak M, Palmer KR, Davies-Tuck M, Bloemenkamp KW, Mol BWJ, Boulvain M. Mechanical methods for induction of labour. Cochrane Database Syst Rev. 2023 Mar 30;3(3):CD001233. doi: 10.1002/14651858.CD001233.pub4.

Reference Type DERIVED
PMID: 36996264 (View on PubMed)

Other Identifiers

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47

Identifier Type: -

Identifier Source: org_study_id

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