Treatment of Sigmoid Volvulus

NCT ID: NCT06771349

Last Updated: 2025-01-14

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 70 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2023-10-01
• Study Completion Date: 2024-12-01

Brief Summary

Colonic volvulus, where part of the colon twists, is a significant cause of large bowel obstruction, representing 15% of cases, second only to cancer and diverticulitis. Acute sigmoid volvulus (SV), which affects the sigmoid colon, is the most common type, with morbidity rates ranging from 6% to 42% and mortality varying from 7% to 90%. The incidence of SV varies globally, being more common in regions such as Africa, Ethiopia, Australia, and East Asia, where it can account for up to 50% of bowel obstructions.

SV often presents as partial or complete obstruction and can lead to severe complications such as ischemia, necrosis, and perforation, especially in older patients. The primary treatment goals are relieving the obstruction, reducing pressure, and correcting the twist. According to the World Society of Emergency Surgery (WSES), endoscopic decompression is recommended for patients without infection, perforation, or hemodynamic instability. However, surgery is necessary if decompression fails, with options including sigmoidopexy, sigmoidectomy, or colostomy. Sigmoidopexy is less invasive but has a higher recurrence rate, while sigmoidectomy, though riskier, may reduce recurrence and improve long-term survival.

This retrospective study aims to compare the outcomes of sigmoidopexy and sigmoidectomy in patients with acute SV undergoing emergency surgery at West China Hospital, Sichuan University, over a 14-year period. The primary outcome is the recurrence rate of SV, with secondary outcomes including 30-day mortality and morbidity (complications).

Detailed Description

Introduction:

Colonic volvulus, a significant cause of large bowel obstruction, occurs when a segment of the colon twists, obstructing normal bowel function. Among the different types of colonic volvulus, acute sigmoid volvulus (SV) is the most common, with a high incidence in certain regions, such as the "twist belt" in Africa, Ethiopia, East Asia, and Australia, where its frequency can exceed 50%. SV frequently presents as either partial or complete bowel obstruction, leading to ischemia, necrosis, and potential perforation if untreated. The morbidity and mortality associated with SV are substantial, particularly in elderly patients. Prompt management is crucial to reduce complications and improve patient outcomes.

Treatment Approaches:

The primary goal of treatment is to relieve the obstruction and address the twisted portion of the colon. The World Society of Emergency Surgery (WSES) recommends endoscopic decompression for patients without signs of severe infection, perforation, or hemodynamic instability. If decompression fails, or if necrosis is present, surgical intervention is necessary. Surgical options include sigmoidopexy, sigmoidectomy, mesenteroplasty, or colostomy. Sigmoidopexy is less invasive but carries a higher risk of recurrence, whereas sigmoidectomy, though more complex, may reduce recurrence and improve long-term survival.

Despite various treatment options, the optimal approach remains unclear due to inconsistencies in the existing literature. This study compares two commonly used surgical methods-sigmoidopexy and sigmoidectomy-to assess their outcomes in terms of SV recurrence, complications, and overall survival.

Methods:

This retrospective study reviewed patients who underwent emergency surgery for acute SV at West China Hospital, Sichuan University, between April 2009 and August 2023. The hospital, a major medical center in Chengdu, China, treats thousands of emergency cases annually. Ethical approval was obtained from the hospital's Ethics Review Board, and informed consent was waived due to the study's retrospective nature.

Inclusion Criteria:

Adults with acute symptoms of intestinal obstruction. Acute SV diagnosis confirmed by CT or surgery. First emergency surgery for acute SV at the hospital.

Exclusion Criteria:

Torsion of parts of the colon other than the sigmoid. Non-surgical management of acute SV or treatment at another institution. Conditions such as bowel perforation or unrelated obstructions. Patients unable to undergo surgery due to poor health.

Primary Outcome:

Recurrence rate of SV after sigmoidopexy or sigmoidectomy.

Secondary Outcomes:

30-day mortality and morbidity, assessed by the Clavien-Dindo classification of complications.

Data Collection:

Data were extracted from the hospital's medical records and supplemented by telephone follow-up with patients or their families. Information collected included:

Demographic details (age, gender, symptoms). Medical history (comorbidities, previous surgeries). ASA score, BMI, surgery details, and post-operative recovery. Surgical duration, hospital stay length, complications, and follow-up data.

Statistical Analysis:

Statistical analysis was conducted using R software (version 4.3.3). Continuous variables were assessed for normal distribution and expressed as means ± standard deviation or medians with ranges. Categorical variables were presented as percentages. For comparing continuous variables, Student's t-test or Mann-Whitney U test was used. For categorical data, Chi-square or Fisher's exact test was applied. A P-value of < 0.05 was considered statistically significant.

Conditions

Sigmoid Volvulus

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

sigmoidopexy group

patients who underwent sigmoidopexy

sigmoidopexy

Intervention Type: PROCEDURE

Both Sigmoidectomy and sigmoidopexy can be used for the treatment of sigmoid volvulus. The former is the treatment of sigmoid volvulus by removing a portion of the sigmoid colon, and depending on the patient's condition, a bowel reconstruction or anastomosis may be performed to reattach the healthy bowel segment. The procedure may result in long-term bowel changes and may even require an stomy. sigmoidopexy is a procedure that immobilizes the sigmoid colon to the abdominal wall or pelvic structure, preventing it from twisting again.

The goal of sigmoidectomy is primarily to remove damaged or necrotic portions of the sigmoid colon and to treat complications resulting from sigmoid volvulus, especially when the volvulus results in intestinal necrosis, ischemia, or other serious complications. The goal of sigmoidopexy is to prevent the sigmoid from re-twisting by immobilizing the sigmoid, and it is suitable for those cases of sigmoid torsion without severe ischemia or necrosis.

sigmoidectomy group

patients who underwent sigmoidopexy without resection

No interventions assigned to this group

Interventions

sigmoidopexy

Both Sigmoidectomy and sigmoidopexy can be used for the treatment of sigmoid volvulus. The former is the treatment of sigmoid volvulus by removing a portion of the sigmoid colon, and depending on the patient's condition, a bowel reconstruction or anastomosis may be performed to reattach the healthy bowel segment. The procedure may result in long-term bowel changes and may even require an stomy. sigmoidopexy is a procedure that immobilizes the sigmoid colon to the abdominal wall or pelvic structure, preventing it from twisting again.

The goal of sigmoidectomy is primarily to remove damaged or necrotic portions of the sigmoid colon and to treat complications resulting from sigmoid volvulus, especially when the volvulus results in intestinal necrosis, ischemia, or other serious complications. The goal of sigmoidopexy is to prevent the sigmoid from re-twisting by immobilizing the sigmoid, and it is suitable for those cases of sigmoid torsion without severe ischemia or necrosis.

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

1. Adult patients presenting with symptoms of acute intestinal obstruction.

2. Diagnosis of acute SV confirmed by the typical "whirl sign" on computed tomography (CT) or laparotomy.

3. First emergency surgery for acute SV performed at our institution.

Exclusion Criteria

1. Torsion of intestinal segments other than the sigmoid.

2. Patients diagnosed with "acute SV" but treated conservatively or operated on at another hospital.

3. Concurrent conditions such as non-SV-related bowel perforation or obstruction.

4. Patients with severe overall states not amenable to surgery.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

West China Hospital

OTHER

Sponsor Role: lead

Responsible Party

Xiaomei Jiang

Resident Physician

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Division of Gastrointestinal Surgery, Department of General Surgery, West China Hospital of Sichuan University

Chengdu, Sichuan, China

Countries

China

Other Identifiers

2023-1601

Identifier Type: -

Identifier Source: org_study_id