Multicenter Study on Suprapubic Catheterization Versus Transurethral Catheterization in Laparoscopic Surgery for Rectal Cancer

NCT ID: NCT02728427

Last Updated: 2018-04-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-04-30

Study Completion Date

2018-10-31

Brief Summary

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Compared with traditional open proctectomy, laparoscopic surgery is associated with less pain, earlier recovery, and better cosmetic outcome, and its long-term oncologic outcomes have been demonstrated. However, the rate of urinary dysfunction after rectal cancer surgery was about 19-38% because of mesorectal excision. The type of drainage is unclear. Some studies show that the rates of urinary tract infection, second catheterization, and urinary symptom are lower with suprapubic catheterization (SPC) than with transurethral catheterization (TUC). Moreover,SPC allows for testing the bladder voiding without drainage removal. Furthermore,SPC using central venous catheter(CVC) is less invasive.

Currently, there is lack of randomized controlled trial(RCT) to compare SPC with TUC. Therefore, investigators perform this prospective randomized trial to compare SPC using CVC with TUC in laparoscopic surgery for rectal cancer.

Detailed Description

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Conditions

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Rectal Cancer Surgery

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Suprapubic Catheterization

Suprapubic catheterization using central venous catheter(CVC-2 7F) will be performed for patients in this group.

Group Type EXPERIMENTAL

Suprapubic catheterization using central venous catheter(CVC-2 7F)

Intervention Type DEVICE

Suprapubic catheterization using central venous catheter(CVC-2 7F) will be performed for patients after laparoscopic surgery for rectal cancer.Suprapubic catheterization is inserted at the end of the procedure. It will be clamped depending on surgeon's specific instruction and removed if the urinary residual is less than 50 cc.

Transurethral Catheterization

Transurethral catheterization using Foley catheter will be performed for patients in this group.

Group Type ACTIVE_COMPARATOR

Transurethral catheterization using Foley catheter

Intervention Type DEVICE

Traditional transurethral catheterization using Foley catheter will be performed for patients.The catheterization is removed on day 5 in patients without complication.

Interventions

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Suprapubic catheterization using central venous catheter(CVC-2 7F)

Suprapubic catheterization using central venous catheter(CVC-2 7F) will be performed for patients after laparoscopic surgery for rectal cancer.Suprapubic catheterization is inserted at the end of the procedure. It will be clamped depending on surgeon's specific instruction and removed if the urinary residual is less than 50 cc.

Intervention Type DEVICE

Transurethral catheterization using Foley catheter

Traditional transurethral catheterization using Foley catheter will be performed for patients.The catheterization is removed on day 5 in patients without complication.

Intervention Type DEVICE

Other Intervention Names

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SPCCVC TUC

Eligibility Criteria

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Inclusion Criteria

* Age over 18 years
* Pathological rectal carcinoma
* Male patients
* Performance status of 0 or 1 on ECOG (Eastern Cooperative Oncology Group) scale
* ASA (American Society of Anesthesiology) score class I, II, or III
* Laparoscopic surgery for rectal cancer
* Written informed consent

Exclusion Criteria

* Emergency surgery due to complication (obstruction or perforation) caused by rectal cancer
* Preoperative T4b according to the 7th Edition of AJCC Cancer Staging Manual
* Basic diseases of urinary system (urinary bladder stones and tumors, prostate cancer, neurogenic bladder, urethral stricture) that affect voiding function
* History of previous pelvic surgery
* Severe mental disease
Minimum Eligible Age

18 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Fujian Cancer Hospital

OTHER_GOV

Sponsor Role collaborator

Fujian Provincial Hospital

OTHER

Sponsor Role collaborator

Nanfang Hospital, Southern Medical University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Guoxin Li, M.D., Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Chinese Laparoscopic Gastrointestinal Surgery Study (CLASS) Group; Nanfang Hospital, Southern Medical University, China

Locations

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Fujian Provincial Hospital

Fuzhou, Fujian, China

Site Status RECRUITING

Fujian Provincial cancer Hospital

Fuzhou, Fujian, China

Site Status RECRUITING

Nanfang Hospital, Southern Medical University

Guangzhou, Guangdong, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Guoxin Li, M.D., Ph.D.

Role: CONTACT

+86-138-0277-1450

jun Yan, M.D., Ph.D.

Role: CONTACT

+86-138-2506-6546

Facility Contacts

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Fangqin Xue, M.D.

Role: primary

+86-137-9995-9360

Weidong Zang, M.D.

Role: primary

+86-13805066578

Chunkang Yang, M.D.

Role: backup

+86-13509333116

Guoxin Li, M.D., Ph.D.

Role: primary

+86-138-0277-1450

Jun Yan, M.D., Ph.D.

Role: backup

+86-138-2506-6546

References

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Bonjer HJ, Deijen CL, Abis GA, Cuesta MA, van der Pas MH, de Lange-de Klerk ES, Lacy AM, Bemelman WA, Andersson J, Angenete E, Rosenberg J, Fuerst A, Haglind E; COLOR II Study Group. A randomized trial of laparoscopic versus open surgery for rectal cancer. N Engl J Med. 2015 Apr 2;372(14):1324-32. doi: 10.1056/NEJMoa1414882.

Reference Type BACKGROUND
PMID: 25830422 (View on PubMed)

Jayne DG, Brown JM, Thorpe H, Walker J, Quirke P, Guillou PJ. Bladder and sexual function following resection for rectal cancer in a randomized clinical trial of laparoscopic versus open technique. Br J Surg. 2005 Sep;92(9):1124-32. doi: 10.1002/bjs.4989.

Reference Type BACKGROUND
PMID: 15997446 (View on PubMed)

Maurer CA, Z'Graggen K, Renzulli P, Schilling MK, Netzer P, Buchler MW. Total mesorectal excision preserves male genital function compared with conventional rectal cancer surgery. Br J Surg. 2001 Nov;88(11):1501-5. doi: 10.1046/j.0007-1323.2001.01904.x.

Reference Type BACKGROUND
PMID: 11683749 (View on PubMed)

Bouchet-Doumenq C, Lefevre JH, Bennis M, Chafai N, Tiret E, Parc Y. Management of postoperative bladder emptying after proctectomy in men for rectal cancer. A retrospective study of 190 consecutive patients. Int J Colorectal Dis. 2016 Mar;31(3):511-8. doi: 10.1007/s00384-015-2471-8. Epub 2015 Dec 22.

Reference Type BACKGROUND
PMID: 26694925 (View on PubMed)

Sethia KK, Selkon JB, Berry AR, Turner CM, Kettlewell MG, Gough MH. Prospective randomized controlled trial of urethral versus suprapubic catheterization. Br J Surg. 1987 Jul;74(7):624-5. doi: 10.1002/bjs.1800740731.

Reference Type BACKGROUND
PMID: 3304522 (View on PubMed)

Ratnaval CD, Renwick P, Farouk R, Monson JR, Lee PW. Suprapubic versus transurethral catheterisation of males undergoing pelvic colorectal surgery. Int J Colorectal Dis. 1996;11(4):177-9. doi: 10.1007/s003840050038.

Reference Type BACKGROUND
PMID: 8876274 (View on PubMed)

Perrin LC, Penfold C, McLeish A. A prospective randomized controlled trial comparing suprapubic with urethral catheterization in rectal surgery. Aust N Z J Surg. 1997 Aug;67(8):554-6. doi: 10.1111/j.1445-2197.1997.tb02037.x.

Reference Type BACKGROUND
PMID: 9287924 (View on PubMed)

Related Links

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http://www.fimmu.com/index_com.html

Southern Medical University, China

http://www.nfyy.com/

Nanfang Hospital, China

http://www.caca.org.cn/

Chinese Anti-Cancer Association

Other Identifiers

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SPCCVC-TUC

Identifier Type: -

Identifier Source: org_study_id

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