Robotic-Assisted or Laparoscopic Radical Resection for Rectal Cancer With or Without Left Colic Artery Preservation

NCT ID: NCT06376227

Last Updated: 2024-04-22

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 1164 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2020-04-01
• Study Completion Date: 2023-12-28

Brief Summary

Brief Summary

Background The preservation of the left colic artery (LCA) during rectal cancer resection remains a topic of controversy, and there is a notable absence of robust evidence regarding the outcomes associated with LCA preservation. And the advantages of robotic-assisted laparoscopy (RAL) surgery in rectal resection remain uncertain. The objective of this study was to assess the influence of LCA preservation surgery and RAL surgery on intraoperative and postoperative complications of rectal cancer resection.

Methods Participants who underwent laparoscopic (LSC) or RAL with or without LCA preservation resection for rectal cancer between April 2020 and May 2023 were retrospectively assessed. The patients were categorized into two groups: low ligation (LL) which with preservation of LCA and high ligation (HL) which without preservation of LCA. A one-to-one propensity score-matched analysis was performed to decrease confounding. The primary outcome was operative findings, operative morbidity, and postoperative genitourinary function.

Detailed Description

The investigators retrospectively collected data from the medical records of participants who had rectal cancer at Northern Jiangsu People's Hospital, from April 2020 to May 2023. A total of 612 from 1164 cases were included in this study; in 462 cases, the LCA was preserved by LL intraoperatively (LL group), in which 202 cases underwent robotic-assisted laparoscopy (LL-RAL subgroup) and 260 cases underwent laparoscopy (LL-LSC subgroup). While in the remaining 150 cases, the LCA was not preserved by HL intraoperatively (HL group). in which 70 cases underwent robotic-assisted laparoscopy (HL-RAL subgroup) and 80 cases underwent laparoscopy (HL-LSC subgroup).

Conditions

Rectal Cancer; Left Colic Artery Stenosis (Diagnosis); Robotic Assisted Laparoscopic Surgery

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

with or without Left Colic Artery Preservation

No interventions assigned to this group

low ligation (LL) group and high ligation (HL) group

low ligation (LL) which with preservation of LCA and high ligation (HL) which without preservation of LCA

with or without Left Colic Artery Preservation

Intervention Type: PROCEDURE

low ligation (LL) which with preservation of LCA and high ligation (HL) which without preservation of LCA

Interventions

with or without Left Colic Artery Preservation

low ligation (LL) which with preservation of LCA and high ligation (HL) which without preservation of LCA

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• Low anterior resection for rectal cancer
• Postoperative pathological diagnosis of rectal adenocarcinoma
• Informed consent signed prior to surgery.

Exclusion Criteria

• Recurrent rectal cancer
• Emergency surgery
• Preoperative and intraoperative detection of distant organ metastases or extensive
• Implantation metastases in the abdominal cavity
• Palliative surgery
• A postoperative pathology report that showed residual cancer cells at the proximal or distal resection margin
• No standard chemotherapy for tumor-node-metastasis (TNM) staging II or III after surgery
• Synchronous colorectal carcinoma and other organ tumors
• Incomplete case data.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Northern Jiangsu People's Hospital

OTHER

Sponsor Role: lead

Responsible Party

Daorong Wang

Doctor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Daorong Wang, M.D., Professor

Role: STUDY_DIRECTOR

Northern Jiangsu People's Hospital

Locations

Northern Jiangsu People's Hospital Affiliated to Yangzhou University, General Surgery Institute of Yangzhou, Yangzhou University , Yangzhou

Yangzhou, Jiangsu, China

Countries

China

Other Identifiers

jamesdukeryan

Identifier Type: -

Identifier Source: org_study_id