Multivisceral Radical Resection for Surgical T4b Colorectal Cancer: Propensity Score-matched Study Comparing the the Laparoscopic and Open Approaches

NCT ID: NCT05707598

Last Updated: 2024-12-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

638 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-01-01

Study Completion Date

2023-01-11

Brief Summary

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This study attempts to compare safety and long-term oncological outcomes between laparoscopic surgery and open surgery in the treatment of clinical T4b Colorectal cancer.

Detailed Description

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Laparoscopic surgery is controversial for patients with T4b colorectal cancer who require multivisceral resection. With the expansion of the indications for laparoscopic surgery in recent years, surgeons try to perform laparoscopic multivisceral resection for the treatment of clinical T4b colorectal cancer. In this study, investigators attempted to compare safety and long-term oncological outcomes between laparoscopic surgery and open surgery in the treatment of clinical T4b colorectal cancer.

This study was a multicenter retrospective cohort study based on a multicenter database which contained hospitalization. According to the operation method, the patients were divided into laparoscopic multivisceral resection group(patients who underwent laparoscopic surgery or conversion to open surgery) and open multivisceral resection group(patients who underwent open surgery directly). The short-term and long-term result was compared between groups.

Conditions

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Colorectal Cancer

Keywords

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Colorectal cancer Multivisceral resection Laparoscope

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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Laparoscopic multivisceral resection group

Patients who underwent laparoscopic multivisceral resection for clinical T4b colorectal cancer

Laparoscopic surgery

Intervention Type PROCEDURE

The laparoscopic approach was used for the treatment of clinical T4b colorectal cancer

Open multivisceral resection group

Patients who underwent open multivisceral resection for clinical T4b colorectal cancer

No interventions assigned to this group

Interventions

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Laparoscopic surgery

The laparoscopic approach was used for the treatment of clinical T4b colorectal cancer

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

1. The patient was pathologically diagnosed as colorectal adenocarcinoma by endoscopic biopsy before operation.
2. All patients were considered to have tumors invading adjacent organs after preoperative radiographic evaluation.
3. All patients were recommended to undergo radical surgery after preoperative multidisciplinary consultation.

Exclusion Criteria

Patients with distant metastasis or recurrent colorectal cancer were excluded.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Cancer Institute and Hospital, Chinese Academy of Medical Sciences

OTHER

Sponsor Role lead

Responsible Party

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Jianqiang Tang

Associate professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Cancer Hospital Chinese Academy of Medical Sciences

Beijing, Beijing Municipality, China

Site Status

Countries

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China

Other Identifiers

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NCC-2023

Identifier Type: -

Identifier Source: org_study_id