Rapid Kidney Function Decline in Older Adults

NCT ID: NCT06765811

Last Updated: 2025-01-09

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 1539 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2011-07-01
• Study Completion Date: 2022-12-25

Brief Summary

This observational study investigates whether a single set of GFR and urine albumin-to-creatinine ratio (ACR) thresholds can accurately screen for rapid kidney function decline in different elderly groups.

Conditions

Kidney Function Decline; Glomerular Filtration Rate; Urine Albumin-creatinine Ratio; Healthy Aging; Comorbidity; Chronic Kidney Disease

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

Rugao Longevity and Aging Study (RLAS) cohort

A total of 1,236 older adults from the Rugao Longevity and Aging Study (RLAS) were enrolled in the study, including 575 healthy aging individuals and 661 with comorbid co-morbidities (e.g., diabetes mellitus, hypertension, coronary heart disease, etc.). The objective of the study was twofold: first, to assess the predictive value of baseline glomerular filtration rate (GFR) to urinary albumin-creatinine ratio (ACR) for rapid decline in renal function (≥30% decline in GFR) within 2 years; and second, to establish early warning criteria for different types of aging populations.

No interventions assigned to this group

Healthcare data from Huashan Hospital, Fudan University (CKD)

The present cohort comprised 303 elderly patients suffering from chronic kidney disease (CKD) from Huashan Hospital of Fudan University, including cases progressing from acute kidney injury (AKI) to CKD. The objective of the study was twofold: first, to assess the predictive ability of baseline GFR and ACR levels for rapid decline in renal function (≥30% GFR) within two years; and second, to establish appropriate early risk assessment criteria for the elderly CKD population.

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

1. Age greater than 70 years;

2. GFR data measured at least twice (two years apart) and ACR data measured once (at baseline);

3. A clear record of the cause of the previous visit; from this, people diagnosed with kidney disease were selected, and kidney disease was defined as various primary nephritis, secondary nephropathy, acute kidney injury (AKI), chronic kidney disease, kidney tumors, or a diagnosis of proteinuria alone.

4. Signed informed consent form.

Exclusion Criteria

1. People with missing baseline biochemical data;

2. Outliers in the population indicators, i.e., data deviating from the mean ± three times the standard deviation;

3. Data with significantly abnormal baseline renal function follow-up (abnormally elevated GFR by more than 10% within 2 years or abnormal ACR value as determined by consultation with a senior nephrologist).

• Minimum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Huashan Hospital

OTHER

Sponsor Role: lead

Responsible Party

Chen Jing

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Jing Chen, PhD, MD

Role: PRINCIPAL_INVESTIGATOR

Huashan Hospital

Locations

Huashan hospital, Fudan university

Shanghai, Shanghai Municipality, China

Countries

China

Other Identifiers

KY2024-1068

Identifier Type: -

Identifier Source: org_study_id