Assessment of Blood Pressure Control and Target Organ Damage in Patients With Chronic Kidney Disease and Hypertension -II

NCT ID: NCT02078115

Last Updated: 2014-03-05

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 400 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2013-04-30
• Study Completion Date: 2015-07-31

Brief Summary

The purpose of this study is to find the change of blood pressure (BP) control pattern (true controlled, white-coat, masked, and sustained uncontrolled/ dipper, non-dipper, reverse-dipper, and extreme-dipper) in patients with chronic kidney disease (CKD) over 3 years. And Other objective is the relationship between the BP control pattern and the target organ damages such as renal function, proteinuria, left ventricular hypertrophy (LVH), and so on. In addition, we will find clinical factors related to the BP control pattern.

Conditions

Chronic Kidney Disease; Hypertension

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

chronic kidney disease, hypertension

20 \<= age \< 75 years 15 \<= estimated glomerular filtration rate (GFR) \< 90

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

1. with informed consent

2. 20 <= age < 75 years

3. diagnosed as hypertension 6 months (or 3 visits) prior to enrollment, taking anti-hypertensive drugs over 3 months

4. all-cause chronic kidney disease patients with 15 <= estimated GFR < 90

5. no change of anti-hypertensive drugs within 2 weeks and good compliance

Exclusion Criteria

1. changed prescription according to ambulatory blood pressure monitoring (ABPM) regularly

2. had acute kidney injury/hospitalization

3. had a proteinuria of > 6 g/day (spot urine protein to creatinine ratio > 6.0 g/g Cr)

4. had end stage renal disease (ESRD) with dialysis and/or were a kidney recipient

5. had diseases, such as uncontrolled arrhythmia, uncontrolled bronchial asthma/chronic obstructive pulmonary disease, or primary endocrinologic diseases except diabetes mellitus

6. were pregnant/lactating women

7. were night shift workers.

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 74 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Seoul National University Hospital

OTHER

Sponsor Role: lead

Responsible Party

Yon Su Kim

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Sung Kyun Kim, MD

Role: STUDY_DIRECTOR

Hallym University Hospital

Locations

Seoul National University Hospital

Seoul, , South Korea

Site Status: RECRUITING

Countries

South Korea

Central Contacts

Sung Kyun Kim, MD

Role: CONTACT

imnksk@gmail.com

Facility Contacts

Ran-hui Cha, MD

Role: primary

reginaprayer@gmail.com

Other Identifiers

Boryung

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

APRODITE-2

Identifier Type: -

Identifier Source: org_study_id