Arterial Stiffness in Chronic Kidney Disease

NCT ID: NCT01770847

Last Updated: 2017-11-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-11-30

Brief Summary

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Diurnal variations in the cardiovascular system apparent in healthy individuals, are different in chronic kidney disease patients. Therefore, diurnal variations in arterial stiffness may also differ in chronic kidney disease patients. This study aims to identify and evaluate diurnal variations in arterial stiffness in chronic kidney disease patients and compare them to those in age matched healthy controls.

Detailed Description

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Conditions

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Chronic Kidney Disease

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Healthy controls

Healthy age matched controls

No interventions assigned to this group

Chronic kidney diease

Chronic kidney disease patients stage 2-4

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Systolic blood pressure \<160 whether or not on antihypertensive medication
* diastolic blood pressure \<100mmHg whether or not on antihypertensive medication
* Chronic kidney disease stage 2-5

Exclusion Criteria

* Systolic blood pressure ≥160mmHg
* Diastolic blood pressure ≥100mmhg
* Significant comorbidity (investigator opinion but to include alcoholism and terminal illness)
Minimum Eligible Age

18 Years

Maximum Eligible Age

79 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Edinburgh

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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David J Webb, MB BS MD DSc FRCP FRSE FMedSci

Role: PRINCIPAL_INVESTIGATOR

University of Edinburgh

Locations

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Clinical Research Centre, 2nd Floor Western General Hospital

Edinburgh, , United Kingdom

Site Status

Countries

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United Kingdom

References

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Dhaun N, Moorhouse R, MacIntyre IM, Melville V, Oosthuyzen W, Kimmitt RA, Brown KE, Kennedy ED, Goddard J, Webb DJ. Diurnal variation in blood pressure and arterial stiffness in chronic kidney disease: the role of endothelin-1. Hypertension. 2014 Aug;64(2):296-304. doi: 10.1161/HYPERTENSIONAHA.114.03533.

Reference Type DERIVED
PMID: 24890823 (View on PubMed)

Other Identifiers

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12\SS\0088

Identifier Type: -

Identifier Source: org_study_id