Neural Changes in Stroke Patients During Challenging Walking Tasks.

NCT ID: NCT06764290

Last Updated: 2025-01-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-04-01

Study Completion Date

2025-02-28

Brief Summary

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For stroke patients, a challenging, unfamiliar, and more difficult task may increase the likelihood of brain activation to stimulate recovery. Pedal walking and walking with eyes-covered are both difficult and challenging tasks for stroke patients. The investigators intend to study the biomechanics and neural mechanisms of challenging pedal walking and walking with eyes covered.

Stroke participants will wear electroencephalogram electrode caps and perform three tasks: walking on a flat surface for 60 seconds, walking on pedal for 60 seconds, and walking with eyes covered for 60 seconds.

Detailed Description

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Stroke participants will wear a 32-lead electroencephalogram electrode cap (Zhentai Technology Company, Xi 'an, China), first walk on a flat ground for 60 seconds, rest for 2 minutes, then walk on the pedal for 60 seconds, rest again for 2 minutes, and walk for 60 seconds with eyes-covered.

Conditions

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Stroke

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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stroke participants

Stroke participants with residual abnormal gait.

pedal walking

Intervention Type OTHER

Pedal walking is a challenging walking task that can be used as a form of physical therapy for stroke participants.

visual occlusion

Intervention Type OTHER

Walking with eyes-covered is a challenging walking task that can be used as a form of physical therapy for stroke participants.

Interventions

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pedal walking

Pedal walking is a challenging walking task that can be used as a form of physical therapy for stroke participants.

Intervention Type OTHER

visual occlusion

Walking with eyes-covered is a challenging walking task that can be used as a form of physical therapy for stroke participants.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* First-time occurrence of stroke confirmed by computed tomography or magnetic resonance imagingClinical diagnosis of stroke
* Disease duration of more than 14 days, less than 1 year
* Able to walk independently but with a lingering abnormal gait

Exclusion Criteria

* Lesions accumulate in the brainstem
* Lesions accumulate in the cerebellum
* Impaired vision
* Severe cognitive impairment
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Nanjing Medical University

OTHER

Sponsor Role lead

Responsible Party

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Zhao Jing

Junior physiotherapist

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Xia Li Zhang, doctor

Role: STUDY_DIRECTOR

Geriatric Hospital of Nanjing Medical University

Locations

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Geriatric Hospital of Nanjing Medical University, 269 Qingmen Street

Nanjing, Jiangsu, China

Site Status RECRUITING

Geriatric Hospital of Nanjing Medical University

Nanjing, Jiangsu, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Jing Zhao, master

Role: CONTACT

+8618817892579

Facility Contacts

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Qian Zhang, Phd

Role: primary

+86 181 68417672

References

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Krakauer JW. Motor learning: its relevance to stroke recovery and neurorehabilitation. Curr Opin Neurol. 2006 Feb;19(1):84-90. doi: 10.1097/01.wco.0000200544.29915.cc.

Reference Type BACKGROUND
PMID: 16415682 (View on PubMed)

Fettrow T, Hupfeld K, Tays G, Clark DJ, Reuter-Lorenz PA, Seidler RD. Brain activity during walking in older adults: Implications for compensatory versus dysfunctional accounts. Neurobiol Aging. 2021 Sep;105:349-364. doi: 10.1016/j.neurobiolaging.2021.05.015. Epub 2021 May 31.

Reference Type BACKGROUND
PMID: 34182403 (View on PubMed)

Kulkarni A, Cui C, Rietdyk S, Ambike S. Humans prioritize walking efficiency or walking stability based on environmental risk. PLoS One. 2023 Apr 7;18(4):e0284278. doi: 10.1371/journal.pone.0284278. eCollection 2023.

Reference Type BACKGROUND
PMID: 37027387 (View on PubMed)

Related Links

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http://pubmed.ncbi.nlm.nih.gov/16415682/

This paper suggests that the rehabilitation of stroke patients may require more challenging tasks

http://pubmed.ncbi.nlm.nih.gov/34182403/

This paper suggests that the performance of complex walking tasks may involve top-down cortical control in the brain centers

http://pubmed.ncbi.nlm.nih.gov/37027387/

This paper shows that the central nervous system will actively respond to environmental changes and adjust to obtain stable motor output

Other Identifiers

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2024018-1

Identifier Type: -

Identifier Source: org_study_id

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