Using of Bone Marrow Stem Cell Concentrate with Platelet Rich Fibrin and Bone Graft in Bone Reconstruction of Upper Jaw Bony Cystic Defects, Comparing with Platelet Rich Fibrin with Bone Graft
NCT ID: NCT06662604
Last Updated: 2024-10-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
PHASE3
22 participants
INTERVENTIONAL
2024-10-26
2026-02-22
Brief Summary
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Detailed Description
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last decade stem cells therapy gained great interest, in many studies Bone marrow stem cells showed promising result in bone regeneration enhancing .
Platelet Rich Fibrin PRF also capability of enhancing bone and tissue regeneration by releasing of certain protein molecules call growth factors that initiate sequential biological events resulting in stem cells migration into the site of bone defect and differentiation to bone formation cells (osteoblast cells ).
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Group A (Stem cells ,PRF group) intervention group
Bone marrow stem cells concentrate , platelet rich fibrin , bone graft
All participants will be treated with Bone marrow stem cells concentrate , platelet rich fibrin , bone graft.
Group B (PRF group)
platelet rich fibrin and bone graft
All participants will treated with platelet rich fibrin PRF , bone graft.
Interventions
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Bone marrow stem cells concentrate , platelet rich fibrin , bone graft
All participants will be treated with Bone marrow stem cells concentrate , platelet rich fibrin , bone graft.
platelet rich fibrin and bone graft
All participants will treated with platelet rich fibrin PRF , bone graft.
Eligibility Criteria
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Inclusion Criteria
* Patients with a critical size maxillary cyst. (\>3 cm)
* Patients that free of any significant medical conditions that could affect healing or outcomes.
Exclusion Criteria
* Patients with significant medical condition
* age under 18 years
18 Years
50 Years
ALL
No
Sponsors
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Cairo University
OTHER
Responsible Party
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Motea Abdulsalam Sanad
Principal Investigator
Central Contacts
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References
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Liu M, Liu Y, Luo F. The role and mechanism of platelet-rich fibrin in alveolar bone regeneration. Biomed Pharmacother. 2023 Dec;168:115795. doi: 10.1016/j.biopha.2023.115795. Epub 2023 Nov 2.
Matsumura-Matsuo M, To M, Okudera T, Matsuo M. Regeneration processes of alveolar bone and microvascular changes after the application of platelet-rich fibrin. J Oral Biosci. 2023 Sep;65(3):218-225. doi: 10.1016/j.job.2023.05.004. Epub 2023 Jun 3.
Fitzsimmons REB, Mazurek MS, Soos A, Simmons CA. Mesenchymal Stromal/Stem Cells in Regenerative Medicine and Tissue Engineering. Stem Cells Int. 2018 Aug 19;2018:8031718. doi: 10.1155/2018/8031718. eCollection 2018.
Manfrini M, Di Bona C, Canella A, Lucarelli E, Pellati A, D'Agostino A, Barbanti-Brodano G, Tognon M. Mesenchymal stem cells from patients to assay bone graft substitutes. J Cell Physiol. 2013 Jun;228(6):1229-37. doi: 10.1002/jcp.24276.
Related Links
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Related Info
Other Identifiers
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OMFS 3-3-18
Identifier Type: -
Identifier Source: org_study_id
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