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Topical Oral Anesthesia Adjuncts in Conventional Intubation on First-Pass Success Rate

NCT ID: NCT06661967

Last Updated: 2024-10-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

110 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-10-25

Study Completion Date

2026-04-30

Brief Summary

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This study aims to determine the first-pass success rate in video laryngoscopy and other parameters that topical anesthesia can affect during intubation.

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Detailed Description

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In Thailand, conventional intubation or sedation without paralysis is still the most common method of intubation due to the lack of emergency physicians at primary care centers. A pilot study had shown that topical oral anesthesia can improve the first-pass success rate in conventional intubation by direct laryngoscopy. This study aims to determine the first-pass success rate in video laryngoscopy and other parameters that topical anesthesia can affect during intubation.

Conditions

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Unrecognized Condition

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

The participants are randomized into two groups. The first group receives lidocaine oral spray during preoxygenation while the latter will receive NSS spray as placebo.
Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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Lidocaine spray

Spray lidocaine 10 puffs at oropharynx during preoxygenation if the patient body weight is lower than 60kg, otherwise 15 puffs

Group Type ACTIVE_COMPARATOR

Lidocaine spray

Intervention Type DRUG

Comparison of the success rate of endotracheal intubations between lidocaine spray and placebo

Placebo

Spray normal saline 10 puffs at oropharynx during preoxygenation if the patient body weight is lower than 60kg, otherwise 15 puffs

Group Type PLACEBO_COMPARATOR

Lidocaine spray

Intervention Type DRUG

Comparison of the success rate of endotracheal intubations between lidocaine spray and placebo

Interventions

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Lidocaine spray

Comparison of the success rate of endotracheal intubations between lidocaine spray and placebo

Intervention Type DRUG

Other Intervention Names

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Placebo

Eligibility Criteria

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Inclusion Criteria

* Patients in emergency department that have indication for conventional intubation
* Age \> 18 yr

Exclusion Criteria

* Patient who undergo RSI
* Patient who falls in cardiac arrest airway algorithm
* Patient who is currently pregnancy
* Known allergy to lidocaine
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Queen Savang Vadhana Memorial Hospital, Thailand

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Queen Savang Vadhana Memorial Hospital

Chon Buri, Changwat Chon Buri, Thailand

Site Status RECRUITING

Countries

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Thailand

Central Contacts

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Sila Thammongkol

Role: CONTACT

[email protected]
0853510161

Facility Contacts

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Sila Thammongkol

Role: primary

[email protected]
0853510161

Other Identifiers

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017/2567

Identifier Type: -

Identifier Source: org_study_id

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