Comparison of Effectiveness Between the Combination of Lidocaine Sprayed at Laryngeal Inlet and on the Cuff of Endotracheal Tube Versus Intravenous Lidocaine for Reducing Cough During Extubation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

164 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-09-01

Study Completion Date

2019-06-30

Brief Summary

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Coughing during extubation of endotracheal tube (ETT) is a common problem that leads to poor surgical results including hemodynamic change, rebleeding at the surgical wound and wound dehiscence. Recently, lidocaine has been introduced for reducing coughing during extubation. However, data comparing routes of lidocaine application are lacking, thus, this study compared the combination of lidocaine sprayed on laryngeal inlet and cuff of ETT versus intravenous lidocaine injection for efficacy in reducing coughing

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Detailed Description

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A prospective randomized control trial was conduct with 164 patients. They were randomly allocated into Gr. A and B. Group A received four puffs of 10% lidocaine sprayed at the cuff of ETT and four puffs at laryngeal inlet whereas Gr. B received 15 mg/kg of 2% lidocaine intravenous injection prior to extubation. The same general anesthesia protocol was applied in all of the patients. Incidence and severity of cough during extubation was evaluated. Furthermore, incidence of 24-hour postoperative adverse events (including sore throat, dysphagia, and hoarseness) and hemodynamic response after extubation were analyzed.

Conditions

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Reducing Cough During Extubation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

The randomized controled trial was conducted. the investigator allocated patient into two arms. Group A received four puffs of 10% lidocaine sprayed at the cuff of ETT and four puffs at laryngeal inlet whereas Gr. B received 15 mg/kg of 2% lidocaine intravenous injection prior to extubation

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

The study based on a sequentially numbered list were prepared in the same way. Participant and outcome assessor were blined to the computer generated lists

Study Groups

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the study group (Group A)

Patients received four puffs of 10% lidocaine sprayed at the cuff of ETT and four puffs at laryngeal inlet

Group Type EXPERIMENTAL

10% lidocaine sprayed

Intervention Type DRUG

four puffs of 10% lidocaine sprayed at the cuff of ETT and four puffs at laryngeal inlet

Comparator group (Group B)

Patients received 15 mg/kg of 2% lidocaine intravenous injection prior to extubation

Group Type ACTIVE_COMPARATOR

2% lidocaine intravenous

Intervention Type DRUG

15 mg/kg of 2% lidocaine intravenous injection prior to extubation

Interventions

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10% lidocaine sprayed

four puffs of 10% lidocaine sprayed at the cuff of ETT and four puffs at laryngeal inlet

Intervention Type DRUG

2% lidocaine intravenous

15 mg/kg of 2% lidocaine intravenous injection prior to extubation

Intervention Type DRUG

Other Intervention Names

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10% Xylociane 2% Xylocaine

Eligibility Criteria

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Inclusion Criteria

* patients who underwent elective surgery with American Society of Anesthesiologists physical status classifications of I and III

Exclusion Criteria

* patients having body mass index more than 35 kg/m2, high risk of aspiration, chronic smokers more than ten pack-years, chronic cough or recent upper respiratory infection, suspected difficult airway, retained ETT prior surgery, surgery at oral cavity, neck and thoracic region, operative time more than 120 minutes or less than 30 minutes, and history of lidocaine allergy

Minimum Eligible Age

19 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No