A Comparison of Pain Severity on Injection of MCT/LCT Propofol Between Lidocaine 20 mg, 40 mg, and Without Lidocaine.
NCT ID: NCT01345981
Last Updated: 2011-05-02
Study Results
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Basic Information
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COMPLETED
NA
210 participants
INTERVENTIONAL
2008-10-31
2009-11-30
Brief Summary
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Detailed Description
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Objective: To compare the severity of pain on injection of MCT/LCT propofol with lidocaine 20 mg, 40 mg, and without lidocaine.
Design: Randomize controlled trial. Method: Two hundred and ten ASA class I - III patients undergoing elective surgery were blinded and equally allocated into 3 groups. Patients in group N, L1, and L2 received MCT/LCT propofol 10 ml mixed with 0.9% NaCl 2 ml, 1% lidocaine 2 ml, and 2% lidocaine 2 ml respectively. Pain at time of propofol injection was assessed by blinded anesthesiologist on a four point scale ; 0 = no pain, 1 = mild pain, 2 = moderate pain, and 3 = severe pain. Results: Patient's demographic data of each group were similar. There were significant differences in the incidence of propofol injection without pain among groups (p\<0.001). The numbers of patients who had moderate and severe pain in groups L1 and L2 were significantly less than those in group N (p\<0.001). The mean blood pressure and heart rate were not significant differences in among groups. Conclusion : The amount of 20 mg, and 40 mg lidocaine to MCT/LCT propofol in our study is equally effective in decreasing pain and more effective than MCT/LCT propofol alone group significantly. They were no significant differences in hemodynamics change in among groups.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
TRIPLE
Study Groups
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lidocaine 20 mg
intravenous lidocaine
Lidocaine
dosage 20 mg and 40 mg
lidocaine 40 mg
intravenous lidocaine 40 mg
Lidocaine
dosage 20 mg and 40 mg
normal saline
2 ml
Lidocaine
dosage 20 mg and 40 mg
Interventions
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Lidocaine
dosage 20 mg and 40 mg
Eligibility Criteria
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Inclusion Criteria
* undergoing elective surgery
* age 18-75 years
Exclusion Criteria
* abnormal liver and renal functions
* has psychological problem or drug abuse
* has recieved analgesic drug 2 weeks prior to surgery
* risk of aspiration
18 Years
75 Years
ALL
No
Sponsors
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Prince of Songkla University
OTHER
Responsible Party
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Department of Anesthesiology Faculty of Medicine Prince of Songkla University Thailand
Locations
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Songklanagarind Hospital
Hat Yai, Changwat Songkhla, Thailand
Countries
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Other Identifiers
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propofol-pain
Identifier Type: -
Identifier Source: org_study_id
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