Predictive Tools for the Presence of Significant Coronary Artery Disease Requiring Intervention in Chronic Hemodialysis Patients

NCT ID: NCT06661941

Last Updated: 2024-10-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

149 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-01-01

Study Completion Date

2023-03-31

Brief Summary

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Medical record data of all HD patients undergoing coronary angiography (CAG) at King Chulalongkorn Memorial Hospital between January 2017 and March 2021 were retrospectively reviewed as a discovery cohort to identify factors discriminating patients with and without significant CAG-established CAD. HD patients receiving CAG between April 2021 and March 2023 were assigned as a validation cohort.

Detailed Description

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Background: Hemodialysis (HD) patients have increased cardiovascular risk. Coronary artery disease (CAD) may not typically manifest in these patients and the investigational results can be confounded by the fluctuation of body fluid and electrolytes. This study explored the accuracy of these findings in identifying CAD in HD patients.

Methods: Medical record data of all HD patients undergoing coronary angiography (CAG) at King Chulalongkorn Memorial Hospital between January 2017 and March 2021 were retrospectively reviewed as a discovery cohort to identify factors discriminating patients with and without significant CAG-established CAD. HD patients receiving CAG between April 2021 and March 2023 were assigned as a validation cohort.

Conditions

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Hemodialysis Coronary Arterial Disease (CAD) ESRD (End Stage Renal Disease)

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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Positive coronary artery disease

Presence of significant coronary artery disease requiring intervention from a coronary angiography result

No interventions assigned to this group

Negative coronary artery disease

Absence of significant coronary artery disease requiring intervention from a coronary angiography result

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* All adult HD patients undergoing CAG at King Chulalongkorn Memorial Hospital of all indications between January 2017 and March 2021 with complete data

Exclusion Criteria

* Those resinged for using their clinical data for the research
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Chulalongkorn University

OTHER

Sponsor Role lead

Responsible Party

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Thana Thongsricome, MD

Thana Thongsricome, MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Faculty of Medicine, Chulalongkorn University

Bangkok, Bangkok, Thailand

Site Status

Countries

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Thailand

References

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Go AS, Bansal N, Chandra M, Lathon PV, Fortmann SP, Iribarren C, Hsu CY, Hlatky MA; ADVANCE Study Investigators. Chronic kidney disease and risk for presenting with acute myocardial infarction versus stable exertional angina in adults with coronary heart disease. J Am Coll Cardiol. 2011 Oct 4;58(15):1600-7. doi: 10.1016/j.jacc.2011.07.010.

Reference Type BACKGROUND
PMID: 21958887 (View on PubMed)

Other Identifiers

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0042/65

Identifier Type: -

Identifier Source: org_study_id

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