Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
3352 participants
OBSERVATIONAL
2007-12-31
2013-05-31
Brief Summary
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In particular, the registry has the following objectives:
* prospective consecutive assessment of all patients with coronary artery disease and renal failure in the participating hospitals of the registry
* evaluation of the outcome and course of patients with regard to their different stages of renal failure at baseline
* analysis of the impact of different therapeutic strategies on acute and long-term outcomes
* identification of clinical risk factors, novel biomarkers and genetic markers for an unfavorable long-term outcome
Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Group 0 (Controllgroup)
eGFR \>= 90 ml/min/1.73m\^2 and no proteinuria
No interventions assigned to this group
Group 1
eGFR \>= 90 ml/min/1.73m\^2 and proteinuria
No interventions assigned to this group
Group 2
eGFR 60 - 89 ml/min/1.73m\^2
No interventions assigned to this group
Group 3
eGFR 30 - 59 ml/min/1.73m\^2
No interventions assigned to this group
Group 4
eGFR 15 - 29 ml/min/1.73m\^2
No interventions assigned to this group
Group 5
eGFR \< 15 ml/min/1.73m\^2 or requiring dialysis
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Patients with actually performed interventional coronary angiography and there a documented coronary heart disease, defined as at least one documented stenosis \>= 50 % in at least one main coronary vessel (Main steam; RCX; RIVA; RCA)
* European/Caucasian descent (European/Caucasian parents and grandparents)
* Availability of an urine, serum- and EDTA blood sample of the patient
* Documented consent of patients for handling of personal medical data, including a genetic analysis
Exclusion Criteria
* Patients with organ transplantations, apart from kidney transplantations
* Immunosuppressive therapy, apart from immunosuppressive therapy after kidney transplantation
* Patients with polycystic renal disease
* Pregnant and breastfeeding patients
* Known malignant tumor
18 Years
ALL
No
Sponsors
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BMBf (Federal Ministry of Education and Research)
UNKNOWN
KfH Kuratorium für Dialyse und Nierentransplantation e.V.
UNKNOWN
Amgen
INDUSTRY
AstraZeneca
INDUSTRY
Boehringer Ingelheim
INDUSTRY
Sanofi
INDUSTRY
Institut für Klinisch-Kardiovaskuläre Forschung GmbH
NETWORK
Principal Investigators
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Eva Brand, Prof. Dr.
Role: PRINCIPAL_INVESTIGATOR
University Hospital of Muenster
Holger Reinecke, Prof. Dr.
Role: PRINCIPAL_INVESTIGATOR
University Hospital of Muenster
Günter Breithardt, Prof. Dr.
Role: PRINCIPAL_INVESTIGATOR
University Hospital of Muenster
Hermann Pavenstädt, Prof. Dr.
Role: PRINCIPAL_INVESTIGATOR
University Hospital of Muenster
Locations
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Universitätsklinikum Aachen
Aachen, , Germany
Zentralklinik Bad Berka
Bad Berka, , Germany
Herz- und Gefäßklinik Bad Neustadt
Bad Neustadt an der Saale, , Germany
Schüchtermann-Klinik
Bad Rothenfelde, , Germany
Herzzentrum Brandenburg
Brandenburg, , Germany
St.-Vincenz-Hospital
Coesfeld, , Germany
Klinikum Lippe-Detmold
Detmold, , Germany
Herzzentrum Duisburg
Duisburg, , Germany
Evangelisches Krankenhaus Düsseldorf
Düsseldorf, , Germany
Alfried Krupp Krankenhaus Essen
Essen, , Germany
Klinikum Garmisch-Partenkirchen
Garmisch-Partenkirchen, , Germany
Universitätsklinikum Halle/Saale
Halle, , Germany
Universitätsklinikum Hamburg-Eppendorf
Hamburg, , Germany
Evangelisches Krankenhaus Hamm
Hamm, , Germany
St. Marienhospital Hamm
Hamm, , Germany
Medizinische Hochschule Hannover
Hanover, , Germany
SLK-Kliniken Heilbronn GmbH
Heilbronn, , Germany
Privatklinik Dr. Schindlbeck
Herrsching am Ammersee, , Germany
Herzzentrum Lahr
Lahr, , Germany
Kardiologische Praxis Dr. Schön
Mühldorf, , Germany
Klinik Augustium München
München, , Germany
Klinikum Neuperlach
München, , Germany
Raphaelsklinik Münster
Münster, , Germany
St. Franziskus-Hospital
Münster, , Germany
Universitätsklinikum Münster
Münster, , Germany
Lukaskrankenhaus Neuss
Neuss, , Germany
Euregioclinic Nordhorn
Nordhorn, , Germany
St. Vincenz-Krankenhaus
Paderborn, , Germany
Klinikum Pirna
Pirna, , Germany
Christliches Krankenhaus Quakenbrück e.V.
Quakenbrück, , Germany
Zentralklinikum Suhl
Suhl, , Germany
Josephs-Hospital Warendorf
Warendorf, , Germany
Countries
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References
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Engelbertz C, Pinnschmidt HO, Freisinger E, Reinecke H, Schmitz B, Fobker M, Schmieder RE, Wegscheider K, Breithardt G, Pavenstadt H, Brand E. Sex-specific differences and long-term outcome of patients with coronary artery disease and chronic kidney disease: the Coronary Artery Disease and Renal Failure (CAD-REF) Registry. Clin Res Cardiol. 2021 Oct;110(10):1625-1636. doi: 10.1007/s00392-021-01864-5. Epub 2021 May 26.
Engelbertz C, Reinecke H, Breithardt G, Schmieder RE, Fobker M, Fischer D, Schmitz B, Pinnschmidt HO, Wegscheider K, Pavenstadt H, Brand E. Two-year outcome and risk factors for mortality in patients with coronary artery disease and renal failure: The prospective, observational CAD-REF Registry. Int J Cardiol. 2017 Sep 15;243:65-72. doi: 10.1016/j.ijcard.2017.05.022. Epub 2017 May 7.
Brand E, Pavenstadt H, Schmieder RE, Engelbertz C, Fobker M, Pinnschmidt HO, Wegscheider K, Breithardt G, Reinecke H. The Coronary Artery Disease and Renal Failure (CAD-REF) registry: trial design, methods, and aims. Am Heart J. 2013 Sep;166(3):449-56. doi: 10.1016/j.ahj.2013.06.010. Epub 2013 Jul 23.
Related Links
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CAD-REF Homepage
Other Identifiers
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1-071812
Identifier Type: -
Identifier Source: org_study_id