Early Renal Replacement Therapy and the Outcome of Acute Kidney Injury

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-01-31

Study Completion Date

2015-12-31

Brief Summary

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This research project is a prospective study to compare mortality between early renal replacement therapy (RRT) and late renal replacement therapy by using plasma neutrophil gelatinase associated lipocalin (pNGAL) as a tool in decision- making.

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Detailed Description

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Conditions

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Acute Renal Failure

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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High NGAL and early RRT

NGAL level \> 400 ng/ml and start continuous renal replacement therapy early

Group Type EXPERIMENTAL

continuous renal replacement therapy

Intervention Type PROCEDURE

High NGAL and late RRT

NGAL \> 400 ng/ml and start continuous renal replacement therapy late

Group Type EXPERIMENTAL

continuous renal replacement therapy

Intervention Type PROCEDURE

Low NGAL

NGAL \< 400 ng/ml and starting continuous renal replacement therapy follow with absolute indication

Group Type ACTIVE_COMPARATOR

continuous renal replacement therapy

Intervention Type PROCEDURE

Interventions

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continuous renal replacement therapy

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* The patient must have given his/her informed and signed consent
* patients with acute kidney injury in the intensive care ward.

Exclusion Criteria

* The patient refuses to sign the consent
* The patient is pregnant, parturient, or breastfeeding
* End stage renal disease
* Chronic renal failure
* previous kidney transplant

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No