Gallbladder Stones in Children and Correlation With Etiological Factors
NCT ID: NCT06660576
Last Updated: 2024-10-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
20 participants
INTERVENTIONAL
2024-10-15
2025-08-01
Brief Summary
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The objective of this study is to estimate the correlation between etiological factors and postoperative histochemical analysis of pediatric gallbladder stones.
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Detailed Description
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A prospective, cohort study. Duration of the study: The study starts from October 2024 to August 2025.
Place of the study:
The study will be held in Department of Pediatric surgery in Sohag University Hospital.
Inclusion and exclusion criteria:
Inclusion criteria:
Age \<18 years . Symptomatic gallbladder stones (biliary colic, fever, vomiting, positive Murphy sign ) .
Congenital hemolytic anemia with gallbladder stones. Asymptomatic patient with gallbladder stones \<5mm after medical treatment (Ursodeoxycholic acid ) for 1year .
Imaging criteria ( large gallbladder stone \< 1cm diameter , gallbladder thickness \>3mm ) either symptomatic or asymptomatic .
Exclusion criteria:
Age \>18 years. Asymptomatic patients who improved after follow up and medical treatment . Biliary anomaly as choledochal cyst , biliary stricture. Common bile duct stones .
Conditions
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Study Design
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NA
SINGLE_GROUP
DIAGNOSTIC
NONE
Study Groups
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Gallbladder stones in children
Histochemical analysis of Gallbladder stones in children and correction with aetiological factors
Cholecystectomy and histochemical analysis of Gallbladder stones
Cholecystectomy and histochemical analysis of Gallbladder stones
Interventions
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Cholecystectomy and histochemical analysis of Gallbladder stones
Cholecystectomy and histochemical analysis of Gallbladder stones
Eligibility Criteria
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Inclusion Criteria
Congenital hemolytic anemia with gallbladder stones. Asymptomatic patient with gallbladder stones \<5mm after medical treatment (Ursodeoxycholic acid ) for 1year .
Imaging criteria ( large gallbladder stone \< 1cm diameter , gallbladder thickness \>3mm ) either symptomatic or asymptomatic .
Exclusion Criteria
18 Years
ALL
No
Sponsors
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Sohag University
OTHER
Responsible Party
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Hitham Diaaeldin Ahmed
M.B.B.Ch., Resident of Pediatric Surgery Sohag University Hospital
Locations
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Sohag university hospital
Sohag, , Egypt
Countries
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Central Contacts
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Nabil Y Abou Eldahab, Professor
Role: CONTACT
Facility Contacts
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Magdy M Amin, Professor
Role: primary
References
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Buch S, Schafmayer C, Volzke H, Becker C, Franke A, von Eller-Eberstein H, Kluck C, Bassmann I, Brosch M, Lammert F, Miquel JF, Nervi F, Wittig M, Rosskopf D, Timm B, Holl C, Seeger M, ElSharawy A, Lu T, Egberts J, Fandrich F, Folsch UR, Krawczak M, Schreiber S, Nurnberg P, Tepel J, Hampe J. A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease. Nat Genet. 2007 Aug;39(8):995-9. doi: 10.1038/ng2101. Epub 2007 Jul 15.
Wesdorp I, Bosman D, de Graaff A, Aronson D, van der Blij F, Taminiau J. Clinical presentations and predisposing factors of cholelithiasis and sludge in children. J Pediatr Gastroenterol Nutr. 2000 Oct;31(4):411-7. doi: 10.1097/00005176-200010000-00015.
Curro G, Meo A, Ippolito D, Pusiol A, Cucinotta E. Asymptomatic cholelithiasis in children with sickle cell disease: early or delayed cholecystectomy? Ann Surg. 2007 Jan;245(1):126-9. doi: 10.1097/01.sla.0000242716.66878.23.
Other Identifiers
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Soh-Med-15-10-7MS
Identifier Type: -
Identifier Source: org_study_id
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