Ultra-Widefield Fluorescein Angiography-Based Targeted Retinal Photocoagulation Versus Conventional Panretinal Photocoagulation in the Preservation of Visual Function and Regression of Proliferative Diabetic Retinopathy

NCT ID: NCT06653361

Last Updated: 2024-10-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-09-01

Study Completion Date

2024-02-28

Brief Summary

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Proliferative diabetic retinopathy is a vision-threatening disease that can lead to irreversible visual loss. The treatment options for proliferative diabetic retinopathy are anti-VEGF injection and retinal photocoagulation. The study aims to compare ultra-widefield fluorescein angiography-based targeted retinal photocoagulation and panretinal photocoagulation in the treatment of proliferative diabetic retinopathy.

Detailed Description

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Conditions

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Proliferative Diabetic Retinopathy - High Risk

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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TRP

Targeted Retinal Photocoagulation

Group Type EXPERIMENTAL

Green laser

Intervention Type PROCEDURE

Green Laser

PRP

Panretinal Photocoagulation

Group Type ACTIVE_COMPARATOR

Green laser

Intervention Type PROCEDURE

Green Laser

Interventions

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Green laser

Green Laser

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* proliferative diabetic retinopathy (PDR) with neovascularization on the disc or elsewhere in the retina

Exclusion Criteria

* Participants with a history of previous history of:
* retinal photocoagulation
* vitreoretinal surgery
* tractional retinal detachment
* epiretinal membrane
* vitreomacular traction
* glaucoma
* uveitis
* media opacities like cataract, corneal opacity, vitreous hemorrhage
* anti-VEGF injections in last 3 months
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Khyber Teaching Hospital

OTHER

Sponsor Role collaborator

Hayatabad Medical Complex

OTHER_GOV

Sponsor Role lead

Responsible Party

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Yousaf Jamal Mahsood

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Khyber Teaching Hospital Peshawar

Peshawar, Khyber Pakhtunkhwa, Pakistan

Site Status

Countries

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Pakistan

Other Identifiers

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306/DME/KMC

Identifier Type: -

Identifier Source: org_study_id

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