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Analysis of FAZ in Diabetic Retinopathy Using OCT Angiography

NCT ID: NCT05140304

Last Updated: 2021-12-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-11-30

Study Completion Date

2022-11-30

Brief Summary

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Study and assessment of characteristic changes in foveal avascular zone during different stages of diabetic retinopathy using OCTA.

Detailed Description

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OCTA is superior to other retinal imaging techniques like fluorescein angiography(FA) as it does not require dye injection, Intravenous dye injection is time consuming and can have adverse side effects. Furthermore, the edges of the capillaries can become blurred due to dye leakage and imaging of the retina can only be 2D when using FA.

OCTA provides both structural and functional (i.e. blood flow) information in tandem. The "corresponding" OCT b-scans can be co-registered with the simultaneous OCT angiograms so the operator is able to scroll through the OCT angiogram like a cube scan. As a result, the precise location of pathology can be viewed on the corresponding OCT b-scans. This makes OCTA a better tool when detecting the exact location of a retinal pathology.

In diabetic retinopathy OCTA can show choriocapillaris abnormalities and/or retinal microvascular abnormalities such as microaneurysms, vascular remodeling adjacent to the foveal avascular zone (FAZ), enlarged FAZ, and capillary tortuosity and dilation through different stages. OCTA can show smaller vascular changes not detectable by FA.

Conditions

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Diabetic Retinopathy

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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A

Group Type OTHER

OCT angiography

Intervention Type DEVICE

OCT angiography of foveal avascular zone in diabetic retinopathy

Interventions

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OCT angiography

OCT angiography of foveal avascular zone in diabetic retinopathy

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Diabetic patients suffering from different stages of diabetic retinopathy.

Exclusion Criteria

* Other ocular problems affecting vision including glaucoma, cataract, amblyopia, hypertensive retinopathy, vein occlusion and uveitis.
Minimum Eligible Age

10 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Kareem Mohammad Ali

OTHER

Sponsor Role lead

Responsible Party

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Kareem Mohammad Ali

Resident

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Ziad Hn El Daly, MD

Role: STUDY_CHAIR

Assuit Universoty

Central Contacts

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Kareem Md Ali, Resident

Role: CONTACT

Phone: +201091319590

Email: [email protected]

Ziad Hn El Daly, MD

Role: CONTACT

Phone: +201091319590

References

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Kim DY, Fingler J, Zawadzki RJ, Park SS, Morse LS, Schwartz DM, Fraser SE, Werner JS. Optical imaging of the chorioretinal vasculature in the living human eye. Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14354-9. doi: 10.1073/pnas.1307315110. Epub 2013 Aug 5.

Reference Type RESULT
PMID: 23918361 (View on PubMed)

Choi W, Mohler KJ, Potsaid B, Lu CD, Liu JJ, Jayaraman V, Cable AE, Duker JS, Huber R, Fujimoto JG. Choriocapillaris and choroidal microvasculature imaging with ultrahigh speed OCT angiography. PLoS One. 2013 Dec 11;8(12):e81499. doi: 10.1371/journal.pone.0081499. eCollection 2013.

Reference Type RESULT
PMID: 24349078 (View on PubMed)

NOVOTNY HR, ALVIS DL. A method of photographing fluorescence in circulating blood in the human retina. Circulation. 1961 Jul;24:82-6. doi: 10.1161/01.cir.24.1.82. No abstract available.

Reference Type RESULT
PMID: 13729802 (View on PubMed)

Other Identifiers

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OCT angiography

Identifier Type: -

Identifier Source: org_study_id