Initial Clinical and CBCT Outcomes of Enamel Matrix Derivative-Based Regenerative Therapy in Vertical Bone Defects

NCT ID: NCT06639555

Last Updated: 2024-10-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

48 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-06-24

Study Completion Date

2023-08-15

Brief Summary

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Study of the effectiveness of the application of regenerative therapy with autogenous, platelet-rich plasma in vertical defects Investigation of the effectiveness of the application of regenerative therapy with enamel matrix derivatives in vertical bone defects Study of the effectiveness of the application of guided tissue regeneration in vertical bone defects with Barrier membrane and Barrier membrane and autogenous platelet-rich plasma

Detailed Description

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Conditions

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Vertical Alveolar Bone Loss

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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PRP alone

Group Type ACTIVE_COMPARATOR

PRP( platelet rich plasma)

Intervention Type PROCEDURE

regenerative therapy with PRP for vertical bone defects

EMD Alone

Group Type ACTIVE_COMPARATOR

EMD (Enamel Matrix Derivative)

Intervention Type PROCEDURE

regenerative therapy with EMD for vertical bone defects

GTR (barrier membrane)

Group Type ACTIVE_COMPARATOR

Guided Tissue Regeneration (barrier membrane)

Intervention Type PROCEDURE

guided tissue regeneration with barrier membrane alone for vertical bone defects

GTR(barrier membrane and PRP)

Group Type ACTIVE_COMPARATOR

Guided Tissue Regeneration(barrier membrane and PRP)

Intervention Type PROCEDURE

guided tissue regeneration with barrier membrane and PRP for vertical bone defects

Interventions

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PRP( platelet rich plasma)

regenerative therapy with PRP for vertical bone defects

Intervention Type PROCEDURE

EMD (Enamel Matrix Derivative)

regenerative therapy with EMD for vertical bone defects

Intervention Type PROCEDURE

Guided Tissue Regeneration (barrier membrane)

guided tissue regeneration with barrier membrane alone for vertical bone defects

Intervention Type PROCEDURE

Guided Tissue Regeneration(barrier membrane and PRP)

guided tissue regeneration with barrier membrane and PRP for vertical bone defects

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* good oral hygiene
* written informed consent
* age
* no systemic diseases

Exclusion Criteria

* smokers
* horizontal bone loss
* untreated periodontium disease
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Tsvetalina Gerova-Vatsova

OTHER

Sponsor Role lead

Responsible Party

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Tsvetalina Gerova-Vatsova

Assistant

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Medical University - Varna

Varna, Varna, Bulgaria

Site Status

Countries

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Bulgaria

Other Identifiers

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118/23.06.22

Identifier Type: -

Identifier Source: org_study_id

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