Treatment of Periodontal Intra-bony Defects With a Volume Stable Collagen Matrix or Deproteinized Bovine Bone Mineral With 10% Collagen
NCT ID: NCT06676826
Last Updated: 2025-10-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
80 participants
INTERVENTIONAL
2025-09-01
2027-12-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Test Group (VCMX)
The periodontal infrabony defect will be opened by a papilla preservation flap, the root surface will be thoroughly cleaned with hand instruments and ultrasonic scalers, then the bony defect will be filled with a volume-stable collagen matrix (VCMX) only.
Infrabony defects will be filled with a volume-stable collagen matrix (VCMX)
Infrabony defects will be filled with a volume-stable collagen matrix
Control Group (Deproteinized bovine bone mineral)
The periodontal infrabony defect will be opened by a flap, the root surface will be thoroughly cleaned with hand instruments and ultrasonic scalers, then the bony defect will be filled with deproteinized bovine bone mineral with 10% collagen.
Infrabony defects will be filled treated with a deproteinized bovine bone mineral with 10% collagen
Infrabony defects will be filled with with a deproteinized bovine bone mineral with 10% collagen
Interventions
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Infrabony defects will be filled with a volume-stable collagen matrix (VCMX)
Infrabony defects will be filled with a volume-stable collagen matrix
Infrabony defects will be filled treated with a deproteinized bovine bone mineral with 10% collagen
Infrabony defects will be filled with with a deproteinized bovine bone mineral with 10% collagen
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Males and females
* Age at least 18 years and older
* Presence of interdental intra-bony defects (I, II and III walls) in either the maxilla or the mandible with a PD ≥ 6 mm
* Defects with an intra-bony component \> 3 mm for both groups
* Intra-bony defect located only at one aspect (mesial or distal)
Exclusion Criteria
* Prolonged antibiotic treatment or anti-inflammatory treatment within 4 weeks prior to surgery
* Pregnant or lactating
* Smokers with \> 10 cig./day
* Patients with FMPS and FMBS \> 25 % after completion of non-surgical periodontal therapy
* Multi-rooted teeth with furcation involvement
* Third molars
* Teeth with circumferential defects
* Interdental craters
* Written Informed Consent
18 Years
ALL
Yes
Sponsors
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University of Bern
OTHER
Responsible Party
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Principal Investigators
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Alexandra Stähli, MD
Role: STUDY_CHAIR
University of Bern
Locations
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University of Bern
Bern, , Switzerland
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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2024-D0026
Identifier Type: -
Identifier Source: org_study_id
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