Effectiveness of Different Membrane Applications in Vertical Ridge Augmentation
NCT ID: NCT04843488
Last Updated: 2024-12-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
30 participants
INTERVENTIONAL
2021-04-15
2023-05-02
Brief Summary
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The primary endpoint is absolute vertical bone gain. The secondary endpoints are regeneration rate, complications rate, and pseudoperiosteum formation.
Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Ridge Augmentation with a perforate PTFE mesh
Vertical and horizontal ridge augmentation will be performed using d-PTFE mesh. The graft material is autograft mixed with a xenograft in a 1:1 ratio.
Guided bone regeneration with a PTFE membrane
Xenograft bovine spongious bone substitute mixed with autogenous intraorally harvested particulated bone is used and spatially contained with a PTFE membrane secured with Ti pins and screws.
Ridge Augmentation with a perforate PTFE mesh covered with a collagen membrane
Vertical and horizontal ridge augmentation will be performed using d-PTFE mesh. The mesh will be covered with a native collagen membrane. The graft material is autograft mixed with a xenograft in a 1:1 ratio.
Guided bone regeneration with a PTFE+collagen membrane
Xenograft bovine spongious bone substitute mixed with autogenous intraorally harvested particulated bone is used and spatially contained with a PTFE membrane secured with Ti pins and screws and covered with a Collagen membrane subsequently.
Interventions
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Guided bone regeneration with a PTFE membrane
Xenograft bovine spongious bone substitute mixed with autogenous intraorally harvested particulated bone is used and spatially contained with a PTFE membrane secured with Ti pins and screws.
Guided bone regeneration with a PTFE+collagen membrane
Xenograft bovine spongious bone substitute mixed with autogenous intraorally harvested particulated bone is used and spatially contained with a PTFE membrane secured with Ti pins and screws and covered with a Collagen membrane subsequently.
Eligibility Criteria
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Inclusion Criteria
2. patients agrees with conditions of the study and sign consent
Exclusion Criteria
* Smoking
* Alcohol or Drug abuse
* acute local or systemic infections
* uncontrolled diabetes or other metabolic disease
* severe hepatic or renal disfunction
* autoimmune disease
* radiotherapy in the last 5 years
* patients receiving immunosuppressive therapy
18 Years
ALL
Yes
Sponsors
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Szeged University
OTHER
Urban Regeneration Institute
OTHER
Responsible Party
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Locations
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Urban Regeneration Institute
Budapest, , Hungary
Countries
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References
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Urban IA, Montero E, Monje A, Sanz-Sanchez I. Effectiveness of vertical ridge augmentation interventions: A systematic review and meta-analysis. J Clin Periodontol. 2019 Jun;46 Suppl 21:319-339. doi: 10.1111/jcpe.13061.
Urban IA, Monje A, Lozada J, Wang HL. Principles for Vertical Ridge Augmentation in the Atrophic Posterior Mandible: A Technical Review. Int J Periodontics Restorative Dent. 2017 Sep/Oct;37(5):639-645. doi: 10.11607/prd.3200.
Plonka AB, Urban IA, Wang HL. Decision Tree for Vertical Ridge Augmentation. Int J Periodontics Restorative Dent. 2018 Mar/Apr;38(2):269-275. doi: 10.11607/prd.3280.
Urban IA, Monje A, Lozada JL, Wang HL. Long-term Evaluation of Peri-implant Bone Level after Reconstruction of Severely Atrophic Edentulous Maxilla via Vertical and Horizontal Guided Bone Regeneration in Combination with Sinus Augmentation: A Case Series with 1 to 15 Years of Loading. Clin Implant Dent Relat Res. 2017 Feb;19(1):46-55. doi: 10.1111/cid.12431. Epub 2016 May 30.
Urban IA, Monje A, Nevins M, Nevins ML, Lozada JL, Wang HL. Surgical Management of Significant Maxillary Anterior Vertical Ridge Defects. Int J Periodontics Restorative Dent. 2016 May-Jun;36(3):329-37. doi: 10.11607/prd.2644.
Urban IA, Serroni M, Dias DR, Barath Z, Forster A, Araujo TG, Saleh MHA, Cucchi A, Ravida A. Impact of Collagen Membrane in Vertical Ridge Augmentation Using Ti-Reinforced PTFE Mesh: A Randomised Controlled Trial. J Clin Periodontol. 2025 Apr;52(4):575-588. doi: 10.1111/jcpe.14129. Epub 2025 Feb 14.
Other Identifiers
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PTFE1
Identifier Type: -
Identifier Source: org_study_id