Necrotizing Enterocolities

NCT ID: NCT06632041

Last Updated: 2024-10-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

70 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-01-01

Study Completion Date

2025-12-31

Brief Summary

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Haematological disturbances in neonates with necrotizing enterocolities

Detailed Description

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Necrotizing enterocolitis (NEC) is an acquired, multifactorial and devastating gastrointestinal disease associated with high morbidity and mortality in preterm neonates. With an incidence of about 7% in infants with BW \< 1500 g and mortality up to 30%, NEC presents as a medical and surgical emergency It is characterized by ischemia, necrosis, and inflammation of bowel wall with invasion by gas-forming organisms and intramural dissection of gas ,characteristicall appearing as pneumatosis intestinalis in radiological and pathological studies. While exact etiology is undetermined, the pathogenesis is believed to be an anomalous innate immune response to an altered, less diverse intestinal microbiota by the highly immunoreactive enterocytes of premature infants, leading to inflammation and tissue necrosis

* in this devastating disease with undetermined etiology. Breast milk feeding, prolonging gestation to avoid prematurity, antenatal steroid, and the use of probiotics/prebiotics are established prevention strategies in NEC
* The hematological abnormalities associated with NEC were first described 25 years ago by Hutter et al.The abnormalities observed in a series of 40 patients with NEC included thrombocytopenia, with
* and without disseminated intravascular coagulation (DIC), neutrophilia or neutropenia, and hemolytic anemia.

Conditions

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Necrotizing Enterocolitis of Newborn

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Neonates with necrotizing enterocolities

Complete blood count

Intervention Type DIAGNOSTIC_TEST

Study haemtological disturbances in neonates with necrotizing enterocolities

Complete blood count

Intervention Type OTHER

Haemtological disturbances in neonates with necrotizing enterocolities

Interventions

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Complete blood count

Study haemtological disturbances in neonates with necrotizing enterocolities

Intervention Type DIAGNOSTIC_TEST

Complete blood count

Haemtological disturbances in neonates with necrotizing enterocolities

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* preterm less than 36 weeks
* Or very low birth weight less than 1500 gram

Exclusion Criteria

* full term
* Normal birth weight ,Preterm with early breast feeding or more than 1500 gm
Minimum Eligible Age

1 Day

Maximum Eligible Age

30 Days

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Assiut University

OTHER

Sponsor Role lead

Responsible Party

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Mervat maher saad zakhary

Principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Central Contacts

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Mervat Maher Zakhary

Role: CONTACT

01026767826

Other Identifiers

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Necrotizing enterocolities

Identifier Type: -

Identifier Source: org_study_id

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