Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
80 participants
OBSERVATIONAL
2024-08-10
2026-03-31
Brief Summary
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Detailed Description
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Neonatal seizures are paroxysmal, repetitive and stereotypical events. They are usually clinically subtle, inconspicuous and difficult to recognize from the normal behaviors of the inter-ictal periods or physiological phenomena. There is no recognizable post-ictal state. The most widely used scheme is of five main types of neonatal seizure.
* Subtle seizures (50%)
* Tonic seizures (5%)
* Clonic seizures (25%)
* Myoclonic seizures (20%)
* Non-paroxysmal repetitive behaviors Neonates with congenital heart disease have a high risk of cerebral lesions, seizures, and neurological impairment. By congenital heart disease, we refer to the group of congenital malformations present at birth that include cyanotic as well as non-cyanotic cardiac lesions.
Neonatal seizures are the most common clinical expression of central nervous system dysfunction in newborns and one of the most frequent neurological emergencies during this stage of life. They are usually the first sign of neurological involvement and an indicator of the risk of mortality and/ or neurological sequelae.
Conditions
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Study Design
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OTHER
PROSPECTIVE
Interventions
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Electroencephalogram (EEG), CT Brain, Echocardiogram
analyze the etiology, electroencephalographic (EEG) findings, neuroimaging, and neurological sequalae of newborns with congenital heart disease who were presented with seizures
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
1 Day
28 Days
ALL
No
Sponsors
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Assiut University
OTHER
Responsible Party
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Mariam Mohamed Mohamed Abdelhameed
Pediatric resident doctor
Central Contacts
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References
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Glass HC, Wirrell E. Controversies in neonatal seizure management. J Child Neurol. 2009 May;24(5):591-9. doi: 10.1177/0883073808327832. Epub 2009 Feb 13.
Plouin P, Kaminska A. Neonatal seizures. Handb Clin Neurol. 2013;111:467-76. doi: 10.1016/B978-0-444-52891-9.00051-8.
Abend NS, Wusthoff CJ. Neonatal seizures and status epilepticus. J Clin Neurophysiol. 2012 Oct;29(5):441-8. doi: 10.1097/WNP.0b013e31826bd90d.
Jensen FE. Neonatal seizures: an update on mechanisms and management. Clin Perinatol. 2009 Dec;36(4):881-900, vii. doi: 10.1016/j.clp.2009.08.001.
Proposal for revised classification of epilepsies and epileptic syndromes. Commission on Classification and Terminology of the International League Against Epilepsy. Epilepsia. 1989 Jul-Aug;30(4):389-99. doi: 10.1111/j.1528-1157.1989.tb05316.x. No abstract available.
Hoffman JI, Kaplan S. The incidence of congenital heart disease. J Am Coll Cardiol. 2002 Jun 19;39(12):1890-900. doi: 10.1016/s0735-1097(02)01886-7.
Samanek M. Congenital heart malformations: prevalence, severity, survival, and quality of life. Cardiol Young. 2000 May;10(3):179-85. doi: 10.1017/s1047951100009082. No abstract available.
Desnous B, Lenoir M, Doussau A, Marandyuk B, Beaulieu-Genest L, Poirier N, Carmant L, Birca A; CINC multidisciplinary team. Epilepsy and seizures in children with congenital heart disease: A prospective study. Seizure. 2019 Jan;64:50-53. doi: 10.1016/j.seizure.2018.11.011. Epub 2018 Nov 26.
Other Identifiers
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convulsions in neonates
Identifier Type: -
Identifier Source: org_study_id
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