Buccal Infiltration of Different Volumes of Articaine for Extraction.

NCT ID: NCT06630819

Last Updated: 2025-05-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

114 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-11-24

Study Completion Date

2026-05-02

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study compares the effectiveness of two different volumes of buccal infiltration of Articaine for the extraction of mandibular posterior teeth. One group receives buccal infiltration of 1.8 ml of 4% Articaine and the other group receives buccal infiltration of 3.6 ml of 4% Articaine.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The most widely and commonly used injection method for the extraction of mandibular posterior teeth is the inferior alveolar nerve block (IANB) technique. However, various complications like pain during injection, transient facial nerve paralysis, trismus, hematoma, and paresthesia are associated with the inferior alveolar nerve block technique.

Local infiltration technique has been proven as a safer and less painful anesthetic injection technique compared to IANB. Unfortunately, the dense nature of cortical bone in the mandibular posterior region hinders sufficient diffusion of anesthetic solution during infiltration. Thus, to achieve an adequate anesthesia for a painless dental extraction of mandibular posterior teeth by infiltration technique, a strong and effective local anesthetic agent having a deeper penetrating property should be used.

Articaine is one of the most widely used local anesthetic agents. It is more potent and has shown more success rate than Lidocaine and Mepivacaine in providing anesthesia in mandibular and maxillary posterior teeth by buccal infiltration diffusibility.

This study compares the effectiveness of two different volumes of buccal infiltration of Articaine for the extraction of mandibular posterior teeth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Buccal Infiltration Articaine Anesthesia

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Group A

Buccal infiltration of 3.6 ml of 4% Articaine

Group Type EXPERIMENTAL

3.6 ml of 4% Articaine

Intervention Type OTHER

Buccal infiltration of 3.6 ml of 4% Articaine.

Group B

Buccal infiltration of 1.8 ml of 4% Articaine

Group Type ACTIVE_COMPARATOR

1.8 ml of 4% Articaine

Intervention Type OTHER

Buccal infiltration of 1.8 ml of 4% Articaine

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

1.8 ml of 4% Articaine

Buccal infiltration of 1.8 ml of 4% Articaine

Intervention Type OTHER

3.6 ml of 4% Articaine

Buccal infiltration of 3.6 ml of 4% Articaine.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* All healthy patients (ASA I) or patients with mild systemic disease with no functional limitations (ASA II)
* Patients aged ≥ 18 years of age.
* Patients requiring extraction of mandibular posterior teeth including grossly decayed tooth, grade I mobile tooth, root stumps and indicated for therapeutic reasons.
* Patients not allergic to the drugs or anesthetic agents used in the surgery.

Exclusion Criteria

* Acute infection at the extraction site.
* Patients indicated for surgical extraction of teeth.
* Patients already taking medications affecting pain assessment.
* Pregnant patients.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Qassim University

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Muhammad Atif Saleem Agwan

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Qassim University

Buraidah, Al Qassim, Saudi Arabia

Site Status NOT_YET_RECRUITING

College of Dentistry, Qassim University

Buraidah, , Saudi Arabia

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

Saudi Arabia

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Muhammad Atif S Agwan

Role: CONTACT

966541651713

Abdul K Azad

Role: CONTACT

00966594914343

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Muhammad Atif S Agwan

Role: primary

966-541651713

Muhammad Atif Agwan

Role: primary

00966541651713

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

608/45/14624

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Hyaluronidase Enzymes and Local Anesthesia
NCT06980363 NOT_YET_RECRUITING PHASE1