Effect of Endurance Training-Induced Coenzyme Q10 (CoQ10) Supplementation on Myokine, Exerkine Secretion and Cognitive Functions in Long-Distance Runners

NCT ID: NCT06619249

Last Updated: 2025-08-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE4

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-08-23

Study Completion Date

2026-07-30

Brief Summary

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The goal of this clinical trial is to learn if CoQ10 amplifies endurance training-induced myokine and exerkine secretion and if those changes influences cognition in long-distance runners.

Does 4-week high-dosage CoQ10 supplementation increase the secretion of myokine, exerkine sercetion? Does the above-mentioned intervention improve the cognitive function in long distance runners?

Participants will:

Take CoQ10 or a placebo every day for 4 weeks. Visit the laboratory once every 4 weeks for checkups and tests. Keep the participants' food and training diary.

Detailed Description

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Conditions

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Health Knowledge, Attitudes, Practice

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

A randomized, double-blind, placebo-controlled, cross-over study
Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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CoQ10-treated participants

The participants will be treated with CoQ10 supplements

Group Type EXPERIMENTAL

CoQ10 supplementation

Intervention Type DIETARY_SUPPLEMENT

Long-distance runners will be supplemented with CoQ10 for 4 weeks in cross-over manner with 4 weeks of wash out period.

Placebo-treated participants

The participants will be treated with placebo

Group Type PLACEBO_COMPARATOR

Placebo supplementation

Intervention Type DIETARY_SUPPLEMENT

Long-distance runners will be supplemented with placebo for 4 weeks in cross-over manner with 4 weeks of wash out period.

Interventions

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CoQ10 supplementation

Long-distance runners will be supplemented with CoQ10 for 4 weeks in cross-over manner with 4 weeks of wash out period.

Intervention Type DIETARY_SUPPLEMENT

Placebo supplementation

Long-distance runners will be supplemented with placebo for 4 weeks in cross-over manner with 4 weeks of wash out period.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* training experienced for minimum 2 years
* running training at least 2 times per week
* Personal Best on 10k (\<50 minutes)

Exclusion Criteria

* taking supplements which can interrupt primary outcomes (vitamin D, omega-3 fatty acids)
* injured in last 6 months to avoid n number reduction
Minimum Eligible Age

30 Years

Maximum Eligible Age

50 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Gdansk University of Physical Education and Sport

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Gdansk University of Physical Education and Sport

Gdansk, , Poland

Site Status RECRUITING

Countries

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Poland

Facility Contacts

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Zbigniew Jost, PhD

Role: primary

+48663892068

Other Identifiers

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AWFiS/2024_3_ZJ

Identifier Type: -

Identifier Source: org_study_id

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